ABSTRACT
The nutritious jujube fruit (Ziziphus jujube Mill.) is a member of the Rhamnaceous family and grows mainly in inland areas of Europe, southern and eastern Asia, Australia and especially northern China. Jujubes have a long history as fruit and medicinal. The main bioactive components are vitamin C, phenols, flavonoids, triterpenoids and polysaccharides. Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound of the hydroxycinnamic acid family found in the hydroethanolic fruit extract of Z.jujuba. This polyphenol has many health-enhancing properties, most of which are relevant for the treatment of metabolic syndrome, including antioxidant, anti-inflammatory, antilipidemic, antidiabetic, and antihypertensive effects. Methods: Molecular docking of COX2 with chlorogenic acid was carried out by AutoDock. Result: The molecular docking result revealed that chlorogenic acid showed encouraging docking score. The docking score found to be -5.15.

ABSTRACT
Pólya thinks the major goal of teaching is to teach students how to ponder. It means that we need not only to give them the knowledge but also to help them improve their ability of using the knowledge and to help them form a good habit of thinking and a good mental state. He also thinks that what the teacher says in class is very important and what is more important is to learn what the students are thinking about. From this standpoint, he presents the three Learning Principles, which is also known as 3 Teaching Principles. These principles are quite practical and are worth practicing and improving in teaching. This article introduces how to use the principles, taking Interpolation Method for example.

ABSTRACT
Simulation-based learning (SBL) is a pedagogical method of teaching and assessing clinical skills across all levels of midwifery education. The SBL is based on implementing scenarios. The stages of a clinical scenario include briefing, action and debriefing. Briefing includes information to guide trainees on the scenario and the objectives. The training of participants in the clinical scenarios begins under the supervision of the instructors which is referred to as action. After each scenario, a debriefing takes place to provide immediate feedback on participants and their performance. Finally, an assessment of the trainees’ attitudes, skills and knowledge, is provided. The skills developed during simulation training are knowledge of algorithms, learning clinical skills and handling emergency situations, developing ethical values and decision-making, self-confidence and competence, communication with the patient and the colleagues, teamwork and leadership, patient safety and finally the satisfaction of being part of a multidisciplinary team. It is highly recommended that simulation is incorporated into midwifery curricula because it combines theory with practice and the development of specialized clinical skills to handle complex situations and get ready for future midwifery care.

ABSTRACT
Escherichia coli, a Gram-negative rod organism and the commonest urinary pathogen causing 60-90% of Urinary infections. Two virulence genes (Pap C and hlyA) had been reported to be involved in Escherichia coli pathogenicity and its resistance to antibiotics. The study aimed at detecting PapC and hlyA in E. coli isolated from clinical specimens in two main Tertiary hospitals (Federal Medical Centre and Niger Delta University Teaching Hospital) in Bayelsa State. One hundred and forty-five specimens were collected and analyzed using the standard Bacteriological technique. Antibiotics Susceptibility testing was carried out using the Kirby Bauer method and Polymerase Chain Reaction (PCR) was employed using ABI 970 amplified Biosystem thermal cycler. The susceptibility pattern showed that 18(90%) isolates were resistant to Nalixidic acid, 16(80%) to Ampicillin, 15(75%) to Ceporex, 14(70%) to Septrin and Augmentin, 12(60%) to Reflacine, 11(55%) to Ciprofloxacin, 9(45%) to Gentamycin, 8(40%) to Tarivid and 4(20%) to Streptomycin. Fifteen PCR products were resolved on 1.0% agarose gel, out of which 8(53.3%) harboured Pap C while 1(6.7%) harboured hlyA. Seven of the eight Pap C-carrying isolates were susceptible to Ciprofloxacin while the HlyA virulence gene enhances the resistance of the organism to Ciprofloxacin. Therefore, the E. coli Pap C gene may be incorporated into Ciprofloxacin production to curb antibiotic resistance.

ABSTRACT
This study investigated the chemical composition of two mistletoe leaves for its ascribed folkloric medicinal uses. The mistletoe leaves used for this research was harvested from Neem plant and Fig plant. Proximate analyses, phytochemical screening, Elemental and antioxidant analysis were carried out on both leaves. Alkaloids, saponin, cardioglycosides, Flavonoids, and steroids varied between mistletoe leaves obtained from Neem and fig trees. Saponins, steroids, and cardio glycosides have higher values in mistletoe of Neem. The concentration of Calcium, magnesium and potassium were high in the mistletoe of Neem. Copper, sodium and chromium was not detected in mistletoe of Fig, while it is present in low concentration in the mistletoe of Neem. The differences in the levels of 2, 2-diphenyl-1-picrylhydrazyl hydrate in the two botanicals under investigation revealed that Mistletoe of Neem has superior antioxidant properties compared to Mistletoe of fig. Mistletoe of Neem contain higher quantities of most of the secondary metabolites therefore, it may be of more pharmacological and nutritional value than mistletoe on fig, thus could have more medicinal and industrial values.

ABSTRACT
STEM integrated education is a modern, global education model that aims to develop high-level human resources in the 21st century. STEM integrated education is in line with the current Vietnamese educational development. Today, the focus is on developing students' abilities and qualities, especially the problem solving and creativity - one of the common competencies that all subjects and educational activities must aim for in the 2018 educational program. Integrated STEM teaching topic (hereinafter referred to as iSTEM) is one of three forms of STEM integrated education organization [1], widely implemented for all types of students in Viet Nam. The iSTEM topic follows an integrated internal, multi-disciplinary or interdisciplinary approach, the content closely following the current general education curriculum. In this article, we apply the research results published in previous articles [2, 3], on criteria and process for building iSTEM topics, building level 3 iSTEM topics and teaching the subject in the framework of pedagogical experimentation. Research methods: document research, model proposal, model operation, pedagogical experiment. Achievements: Level 3 iSTEM teaching topic document "Automatic hand washing machine to prevent Covid 19."