ABSTRACT
Background: An inflammatory, prevalent, and chronic skin disease is psoriasis. The term "classic skin lesions" refers to the erythematous, scaly, and well-defined plaques that are frequently located on the extensor surfaces. There have also been several psoriasis variations reported, such as the guttate, erythrodermic, pustular, and palmoplantar types. Psoriasis is typically diagnosed clinically, although distinctive histologic findings include a lymphocytic infiltration, dilated blood vessels, and hyper- and parakeratosis of the epidermis. Although the exact cause of psoriasis is unknown, genetic and environmental factors have been linked to the immune-mediated disease. Many health advantages are associated with flavonoids, such as their antiviral, anticancer, and antioxidant qualities. They also have cardio- and neuroprotective properties. The kind of flavonoid, its (potential) method of action, and its bioavailability all affect these biological functions. These reasonably priced pharmaceutical ingredients contain substantial biological activities and have been shown to be beneficial for a range of illnesses. Purpose: The present study was conducted to evaluate the efficacy of new flavonoid derivatives for their anti-psoriatic potential. Methodology: The scientific validation of the present work was conducted using a computational molecular docking analysis of the lead compounds luteolin, baicalein, and myricetin against the PDE4 enzyme. Result: The results of the current analysis indicate that the selected lead compounds are efficient anti-psoriatic agents, demonstrating binding affinities to the target protein PDE4 with binding energies of -7.269, -7.16, and -6.64 kcal/mol for baicalein, luteolin, and myricetin, respectively. Conclusion: The results demonstrated that each chosen lead compound for further study exhibited substantial inhibitory efficacy against PDE4, hence indicating its potential as an anti-psoriatic drug.

ABSTRACT
Background and objective: Free radical chain reaction is a condition where there is an imbalance between free radicals and antioxidants in the body. This imbalance can lead to cellular and tissue damage, which is of particular concern in the context of cognitive decline associated with diabetes. The aim of this study was to identify molecular and cellular markers of oxidative stress in diabetic rats. Material and methods: The study involved 24 Wistar rats, classified into 3 groups, normal (GT), untreated diabetic (DTN) and treated with D-erythrodihydrosphingosine (inhibitor of Sphingosine kinases 1 and 2) (DTT), fed glucose and food to prevent hypoglycaemia, and subjected to the behavioural test including the 8-arm radial maze. RT-PCR was then used to assess the expression of pro-oxidant (8-hydroxydeoxyguanosine: 8-OHGD) and anti-oxidant (glutathione: GSH and superoxide dismutases: SOD) markers of oxidative stress. Results: The study compared GT with DTN and DTT in a maze task and showed that diabetes affects working memory in diabetic rats. GSH and SOD levels varied according to health status and treatments administered. High levels of GSH and SOD in DTT and DTN suggest high oxidative stress. Low levels in GTs indicate a normal state without significant oxidative stress. The study also found a significant difference between rat groups in the expression of 8-OHGD in the prefrontal cortex. Untreated diabetic rats had higher levels of 8-OHGD, indicating increased oxidative DNA damage due to the oxidative stress associated with diabetes. This shows that diabetes causes increased production of free radicals, leading to cell damage. Conclusion: This work shows that diabetes induces cognitive decline via oxidative stress.

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Background: Metabolic acidosis is a common complication in patients with chronic kidney disease (CKD) that accelerates disease progression and worsens overall health outcomes. Objective: This study compares the safety and effectiveness of sodium citrate and sodium bicarbonate in treating metabolic acidosis in CKD patients to determine the optimal therapeutic approach. Method: A prospective randomized clinical trial was conducted at the Department of Anesthesiology and ICU, Shaheed Monsur Ali Medical College and Hospital, Dhaka, Bangladesh, from October 2023 to September 2024. A total of 132 CKD patients with metabolic acidosis were randomly assigned to two groups: Group A (66 patients) received sodium citrate, and Group B (66 patients) received sodium bicarbonate. Safety, efficacy, and acid-base balance were monitored over 12 months. Results: Both sodium citrate and sodium bicarbonate significantly improved serum bicarbonate levels and reduced blood acidity. In Group A, 85% of patients showed a 50% reduction in acidemia, compared to 78% in Group B. However, Group A demonstrated superior gastrointestinal tolerance (10% side effects) compared to Group B (25% side effects). Sodium citrate also improved bone health markers, with a 15% improvement in calcium levels, while sodium bicarbonate patients had a 10% increase. However, sodium bicarbonate was more cost-effective. Conclusions: Sodium citrate appears to be more effective and better tolerated than sodium bicarbonate in treating metabolic acidosis in CKD patients, though cost considerations may influence therapeutic choices.

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Chemical poisoning is a threat to the health of both children and adults in the Niger Delta region. Nevertheless, the study of the prevalence of poisoning has been undermined in Bayelsa state. Chemical poisoning remains an important health concern in Nigeria, especially in the south-south Niger Delta states which are rich in natural fuel. Information on the prevalence in the Niger Delta region is quite scarce, especially in Bayelsa state. The study investigated the risk factors, awareness, and perception of chemical poisoning, and the prevalence among residents of Amassoma and Yenagoa. A descriptive research employed systematic random sampling of 400 residents from Amassoma and Yenagoa from ages 15 years and above, by administering questionnaires and, collecting data. Data were analyzed using SPSS software utilizing ANOVA. The percentage of awareness of chemical poisoning is 28.4% and the majority of the respondents are educated at the tertiary level with a percentage of 51.5%. The female gender was more with a percentage of 51.0%. Among the signs and symptoms of chemical poisoning, nausea or stomach upset has a percentage of 74.6% being the highest percentage, and stomach cramps have a percentage of 72.9% while having a percentage of 56.7%. About 95.5% of respondents concurred to contacting qualified healthcare providers when poisoning is suspected and 93.8% agreed to keep all chemicals out of reach of children as a preventive measure. It can be concluded that the overall prevalence of chemical poisoning is quite low though used intentionally in young adults for suicide. It can also be said that there is proper awareness of the preventive measures for unintentional poisoning.

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Objectives: The purpose of this study is to determine the normal hematological values and those of some biochemical parameters of the students of the city of Gagnoa (Côte d’Ivoire). Design et Methods: The study was conducted in 184 adolescents (94 girls and 90 boys), aged 11 to 18 years old, recruited in moderne high schools of Gagnoa. The hematological values were determined using an automatic analyzer (Sysmex XP3000, France). The concentrations of biochemical parameters (albumin, protein total, cholesterol total, triglycerides, calcium, magnesium, chloride, potassium and sodium) were determined by spectrophotometer (KENZA MAX BioChemis Try, France) on the venous blood samples were taken from the fold of the elbow with an empty stomach. The results were treated with the statistical analysis software XLSTAT-PRO 7.1. 2018. Results: The median values of red blood cells were 4.5,106/µL (girls) and 4.9,106/µL (boys). The median values of hemoglobin in girls was 12.3 g/dL and among boys was 13 g/dL. The median values of hematocrit girls was 35.9 % and boys was 38 %. The median values MCV were 79.3 fL (girls) and 77 fL (boys). The median values of MCH were 27.6 pg/cell among girls and 26.9 pg/cell among boys. The median values of MCHC girls 34.5 g/dL and boys 34.8 g/dL. The médians values of white blood cells were 6.1.103/µL among girls and 5.8.103/µL among boys. The median values of granulocyte were 2.2,103/µL among girls and 2.4, 103/µL among bboys. The median values of lymphocytes among girls and boys were the same (3,103/µL). The median values of monocyte were 0.7, 103/µL among girls and 0.6 103/µL in boys. The median values of platelet among girls and boys were equal to 247,103/µL and 242,103/µL. The median valeues of protein total among girls and boys were 68 g/L and 69 g/L. The median values of albumin were respectively 47 g/L and 45.7 g/L among girls and boys. The median values of cholesterol total in girls and boys were the same (1.3 g/L). The median values .....

ABSTRACT
Consciousness of facial care among all age groups has become a global demand. In this scenario Toner becomes a game-changer adding formula to remove impurities, prepares the skin for next skincare steps, balances the pH levels, and restores moisture which is essential for maintaining a healthy and vibrant complexion. As our face harbours a diverse microflora regularly, such products should be tested for their antimicrobial efficacies to establish a scientific bridge. Hence, our study aimed to evaluate the antimicrobial effects of some popular toners against face isolates. For this study, bacteria were isolated from the face of ten persons and identified partially through cultural, microscopic and biochemical observations. Also the antibiotic sensitivity pattern of those face microflora was studied against different antibiotics. The isolates were resistant towards Chloramphenicol, Ampicillin, Amoxicillin, Penicillin and Cefixime, however they were found sensitive towards Kanamycin, Gentamycin, Ciprofloxacin, Tetracycline, and Azithromycin. For the key work nine numbers of most accepted toners were selected to check their antimicrobial activities against those isolates. Biotique toner showed excellent antimicrobial activity against all the isolates. Hence it is recommended to add toners to every day practices to prevail over microbial accumulation on face leading to various discomforts.

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This study aimed to determine the antibacterial effect of the extract of Nymphaea alba petals, and if antibacterial activities are present then the Minimum Inhibitory Concentration (MIC) of the extract is determined. Currently multidrug resistant bacteria are a major concern for clinicians as most conventional antibiotics do not work against MDR strains and infections with MDR strains are increasing day by day, with many resulting in death. This study focused mainly on the antibacterial activity of ethanol extract. Our study showed that the crude extract is significantly effective against MDR Pseudomonas aeruginosa and Klebsiella pneumoniae with MIC value <0.78 mg/ml. This confirms the effectiveness of this extract against MDR bacteria.