ABSTRACT
As Non-steroidal anti-inflammatory drugs plays a critical role in the management of multiple disorders, the demand of its existence in the clinical therapeutics is crucial. Hence, in this study synthesis, characterisation, and biological evaluation of novel benzofuran derivatives were performed. All synthesized compounds were purified by successive recrystallization from the appropriate solvents. The purity of compounds was checked by the TLC (thin layer chromatography). The characterization was done based on MP (melting point) determination and its properties was examined through TLC, FT-IR, 1H NMR, 13C NMR and mass spectroscopy. The anti-inflammatory activity of novel Benzofuran derivatives was estimated by rat paw oedema in vivo anti-inflammatory assay.

ABSTRACT
Multiple Sclerosis is an extremely frequent non-traumatic debilitating illness affecting youngsters. Multiple Sclerosis is becoming more common across the globe, as is the disease's economic effect. The fundamental etiology of Multiple Sclerosis plus the processes causing this rise remain unknown, yet complicated interactions between genes and the environment virtually definitely play an important part. The major source of injury in MS is swelling of the brain and spinal cord. The exact ingredients that cause this type of inflammation are unclear. According to research, environmental, genetic, and viral causes may all have a role in the onset of MS. MS statistics suggests that reduced blood vitamin D levels, cigarette smoking, obesity in kids, and Epstein-Barr virus infection all have a role in disease progression. Because of advancements in diagnostic procedures and standards, patients with MS can now be identified at a younger age. Along with this, the quantity, effectiveness, and danger of MS therapies have risen tremendously. The prospect of a 'pre-symptomatic MS' diagnosis, which might lead to the investigation of possible preventative therapies. MS epidemiological studies, probable aetiological variables, and pathogenesis are all reviewed throughout this detailed study prior proceeding on to therapeutic elements of MS diagnostic and therapy. Recent encouraging investigations of condition-modifying medications in progressive form of MS offer persons alongside severe MS the hope of slowing the progression of the disease while keeping residual functioning. It turns out that drugs appear to work at several stages of the illness's progression puts challenge on the traditional two-stage model of MS's inherent course.

ABSTRACT
Nanoparticles (NPs) occupy a superior place among the recent approaches experimented to deliver drugs into brain by circumventing the BBB such as chemical modifications. The Emulsification PEG-PLGA nanoparticles carrying drug were made using the solvent evaporation method. In summary, PEG-PLGA was dissolved in acetone (50 mL) and PLGA was dissolved in PEG-PLGA (50:50, 7-11 mg/mL). The Chitosan-Avastin conjugates were created in the lab in accordance with the procedures and guidelines outlined in Chitosan (3.25 m mol) was hydrated in 1 N HCl, then the appropriate amount of distilled water was added. After adding NaOH (5N) to the reaction mixture to get the pH down to 5, Avastin (6.48 mmol) was added while the mixture was continuously stirred. In-vitro studies the basic aim is to check the effect of various drugs on various cancer cell lines. For testing purpose a large number of human cancer cell lines have been screened. Cells are cultivated in 96-well culture plates, and the rate of cell multiplication, which determines the rate of cell growth, is indirectly measured by the dye's color intensity, which is directly inversely proportional to the number of cells present. Using doses between 10 and 100 g/mL, the MTT test was performed to examine the cytotoxicity various polymer ratios and formulations on human lung cancer lines-A549. For the determination of the percentage of viability of various samples, the cancer cells without receiving therapy were utilized as the control.

ABSTRACT
Medical Laboratory Science (MLS) is a vital component of the health care system that provides diagnostic services and contributes to medical research. In India, MLS has been evolving rapidly in terms of technology, education, regulation, and quality. This paper aims to provide a comprehensive overview of the current status and future prospects of MLS in India, with a focus on the challenges and opportunities faced by the professionals and stakeholders involved in this field. The historical development and scope of MLS in India is described, highlighting the various roles and responsibilities of MLS professionals in different settings. Further, the current trends and innovations in MLS, such as molecular diagnostics, point-of-care testing, automation, and role of artificial intelligence are discussed. The major challenges and gaps are highlighted that need to be addressed to improve the quality, accessibility, affordability, and sustainability of MLS services and infrastructure in India, such as the lack of standardization, regulation, accreditation, recognition, training, and research. Moreover, the opportunities and initiatives that can enhance the capacity and contribution of MLS services in India are mentioned, such as the adoption of new technologies, innovations, and best practices; the strengthening of human resources, education, and collaboration; the development of ethical and legal frameworks; and the creation of an enabling environment for MLS innovation and adoption. The paper intends to provide a comprehensive overview of the emerging landscape of MLS in India and to inspire further research and discussion on this topic.

ABSTRACT
Nanotechnology serves as a new approach in the treatment of many diseases which has very large number in the morbidity and mortality. Biosensing and molecular imaging assisted with nanotechnology helps in identifying and diagnosis of many diseases. These nanomaterials also helps in the targeted drug delivery to the specific region. The existence of nanomaterials have become increased over the period of 40 years. Nanoparticles helps in the diagnosis of several diseases especially detection of cancer biomarkers. This technology also has a greater ability in the management of neurodegenerative diseases such as Alzheimer’s disease, autoimmune diseases, skin diseases, renal diseases, tuberculosis and cancer. It also extended its application to targeted drug delivery, diagnosis and pharmacogenetics to individualize the treatment options for several diseases and disorder. Apart from this, nanoparticles also showed more efficiency for antimicrobial, antifungal and antiviral therapies. Nanotechnology has greater applications in the medical and pharmaceutical field due to its unique characteristics. Due to their smaller size, these nanomaterials have the ability to penetrate deeper into the biological tissues or skin and can elicit their therapeutic activities. Nanotechnology extended its application in the recent pandemic COVID-19 by the production of vaccines using lipid nanoparticles and also conquered the difficulties faced by the normal drug delivery systems. In this article, we can discuss about the various types and applications of nanotechnology.

ABSTRACT
Quercetin is a polyphenol derived from many fruits and vegetables which is known for its antioxidant, anti-hypertensive and anti-inflammatory properties. This comes under the class flavonoids. Polyphenols consists of many phenol structures in it and is not synthesized in the human body. These polyphenols exhibit its anti-oxidative effects by stimulating the anti-oxidant enzymes such as glutathione peroxidase and catalase. Quercetin is present in many plant based substances such as onion, apple, broccoli, hypericum, cherries, green tea and etc. Quercetin as many therapeutic effects such as anti-oxidant, anti-inflammatory and anti-aging. It also plays significant role in many diseases and disorders such as hypertension, type 2 diabetes mellitus, anxiety, depression, neurodegenerative disorders, Huntington’s disease and cardiovascular diseases such as atherosclerosis, etc. Quercetin up regulates the enzyme Sirtuin 1, is an enzyme which is also present in many plant based substances. This Sirtuin 1 also plays a pivotal role in the many age-related diseases and disorders. The primary objective of this article is to study the therapeutic effects of quercetin and its role in controlling the major age-related diseases and disorders based on several studies. This article also highlights the potential bio enhancer property of quercetin in many class of drugs such as anti-viral, anti-hypertensive, anti-fungal, anti-tuberculosis and anti-cancer drugs.

ABSTRACT
Background/ Objective: plants that function primarily to maintain individual health and improve the quality of life throughout the year. a traditional plant as traditional medicine is dragon tail leaves (R. pinnata (L.f.) Schott.). Therefore, this review aims to share reports and provide a comprehensive explanation of the phytochemical and pharmacological activities of (R. pinnata (L.f.) Schott.). Methods: evaluation shared facts in the literature on phytochemical activity and pharmacological activity (R. pinnata (L.f.) Schott.) through 2012-2022. Three bibliographical databases were used to obtain the main report (Pubmed, Science Direct, and Google Scholar). The keywords in this search were “Pharmacology”, “Phytochemicals”, “(R. pinnata (L.f.) Schott.)” and “Bioactive compounds”. Results: a total of 17 studies classified as this evaluation fulfilled the criteria, 8 included and 9 included pharmacological.R. pinnata (L.f.) Schott contains phenolics, alkaloids, flavonoids, tannins, triterpenoids/steroids, and saponins. A series of pharmacological studies have reported on the plant R. pinnata (L.f.) Schott has the effect of Anticancer, Anticancer breast, Antibacterial, Antimutagenic, burns, Analgesic, anti hyperuricemia, and antihyperglycemia. Conclusions: Recent interest in traditional medicine from plants R. pinnata (L.f.) Schott exhibits potential activity against pharmacological effects associated with the presence of pure bioactive compounds.