ABSTRACT
Myocardial infarction and related cardiovascular complications are the main causes of deaths throughout the world. The use of herbal antioxidants is increasing as defensive agents against number of cardiovascular abnormalities. The bioactive agents from natural sources have gained fundamental importance in modern system of medicines, reducing the risks of cardiac ailments by scavenging the free radicals formation. Phoenix dactylifera L. is a fruit bearing tree with a lot of prospects. Its fruits, and seeds otherwise known as pit and by products are made up of nutritional and medicinal potentials. The ethanolic extract of Phoenix dactylifera fruit was studied for the cardio protective and antioxidant activity against Isoproterenol induced myocardial infarction in wistar albino rats. Phoenix dactylifera showed significant cardio protective effect by reversing the cardio biomarkers (CK-MB, LDH) and oxidative stress markers (SOD, GSH, GPX, CAT, LPO) induced by Isoproterenol. The findings of cardio biomarkers from serum and oxidative stress markers from myocardial tissue in the present work are comparable with the reference control Vitamin E. The results conclude that ethanolic extract of Phoenix dactylifera showed cardio protective activity and the effect may be mediated by its antioxidant potential.

ABSTRACT
Myristica fragrans is commonly named nutmeg or mace belongs to family Myristicaceae. It is an aromatic evergreen tree with spreading branches and a yellow fleshy fruit similar in appearance to an apricot or peach. Myristica fragrans essential oil has antimicrobial, antiseptic, antiparasitic, anti-inflammatory, and antioxidant properties. We have recently demonstrated that hydrodistillation of nutmeg essential oil by applying magnesium aluminometasilicate as an excipient significantly increases both the content and amount of bioactive substances in the oil and hydrolats. In this study, we aimed to compare the antioxidant, antimicrobial, and anti-inflammatory activity of hydrolats and essential oil obtained by hydrodistillation in the presence and absence of magnesium aluminometasilicate as an excipient. Caribbean islands of Grenada and Trinidad are also influential in growing this aromatic tree commercially. It belongs to Myristicaceae family and is the source of two spices, nutmeg (Jaiphal) and mace (Javitri). Nutmeg is the seed kernel inside the fruit and mace is the fleshy red, net-like skin covering (aril) on the kernel. Further, studies divulge the occurrence of different chemical constituents like Myristicin, Macelignan and Eugenol (4-allyl-2-methoxyphenol). Nutmeg possesses various pharmacological activities like hepato protective activity, anti-oxidant activity, memory enhancing activity, cytotoxicity, aphrodisiac activity, anti-diabetic activity, anti-depressant activity, hypolipidemic and hypocholesterolemic effect, anti-microbial activity, antibacterial, anti-inflammatory, anti-carcinogenic activity, flavouring properties and pesticidal activity. This article reviews various pharmacological properties of this medicinal plant.

ABSTRACT
GRP78 is a reticulum-based molecular chaperone that helps fold and assemble protein, controls protein stability, and regulates ER tension signals via Ca2+ attachment to ER. Tumours consistently upregulate GRP78. It functions as a critical stress sensor that recognises and adapts to shifts inside the tumour’s microenvironment, mediating cancer cell stress in response to various microenvironmental stimuli and triggering a folding protein response. GRP78 is increasingly related to increased lung cancer and lousy prognosis and plays an essential role in treating lung cancer. We first investigated its role and mechanism in tumorigenesis, apoptosis, autophagy, proliferation, and drug tolerance to better understand GRP78's involvement in lung cancer pathology. We have researched GRP78's function as a pronounced biomarker and a lung cancer therapeutic goal to detect and cure lung cancer.

ABSTRACT
Formulation of drugs in liposomes has provided an opportunity to enhance the therapeutic indices of various agents mainly through alteration in their bio distribution. Liposomes are a novel drug delivery system (NDDS), they are vesicular structures consisting of bilayer which form spontaneously when phospholipids are dispersed in water. They are microscopic vesicles in which an aqueous volume is entirely enclosed by a membrane composed of lipid bilayers. The goal of any drug delivery system is spatial placement and temporal delivery of the medicament. Research works are going on to prepare an ideal drug delivery system which satisfies these needs. Liposomes are small vesicles (100 nm) composed various lipid molecules which build their membrane bilayers. These formulations are mainly composed of phosphatidylcholine and other constituents such as cholesterol and lipid-conjugated hydrophilic polymers. Liposomes are biodegradable and biocompatible in nature.

ABSTRACT
Abscess is a localised collection of pus contained with a cavity and it is widely affected skin, anal area, tooth pulp etc. It cause swallowing, pain ,fever, the main cause of abscess is incision ,bacterial infection ,wounds and it can be diagnosed by CT scan, MRI, X-ray and radioisotopes scaning. It can be treated by using some antibiotic ,surgery but most promising treatment is homeopathic treatment because this treatment is fully cure the disease and it decreased chance of reoccurrence but it has contain a longer time.

ABSTRACT
Background: Diabetes mellitus is a high prevalence disease that increases and requires continuous treatment. However, antidiabetic drugs can cause side effects in long-term use. Traditional medicine derived from natural sources such as mangosteen (Garcinia mangostana Linn.) is potential as one of the solutions as an antidiabetic drug. α-mangostin has an antidiabetic activity where this compound lowers blood glucose levels and normalize hyperglycemic conditions. This review summarized the antidiabetic activity of G. mangostana and α-mangostin compound in the mangosteen (G.mangostana Linn) plant. Method: We reviewed and compiled published articles search through several sites such as Google Scholar, NCBI, Pubmed, Research Gate, and Science Direct within the last ten years. Result: Several studies show an antidiabetic effect from G. mangostana and α-mangostin observed from several parameters, including blood glucose levels, plasma insulin, HOMA-IR values, histopathology examination, and others. Conclusion: G.mangostana extract and α-mangostin are promising candidates for the treatment of diabetes.

ABSTRACT
Objectives: We reviewed the types of monoclonal antibodies being repurposed for COVID-19 therapeutics, the clinical outcomes and adverse effects so as to provide evidence the bedside physicians, the health policy-makers and the general public could employ in the COVID-19 management protocol. Data sources: We searched PUBMED, Google Scholar and SCOPUS. In addition, snow-balling of the selected articles were carried out to identify additional potentially relevant articles. All relevant articles up to 25 May 2020 were identified. Relevant preprints were also included. Study selection: Our search strategy identified 396 potentially relevant articles which decreased to 322 after duplicates were removed. 281 articles were screened out due to lack of relevance, using the Joanna Briggs Institute’s critical appraisal checklists for evaluation of the quality of studies. The full text of the remaining 41 relevant papers were retrieved for full text evaluation after which only 19 studies from eight countries met our eligibility criteria and were included in the review. Data extraction: Three of the authors independently extracted data from the eligible journals using pre-designed MS tables. The results were compared and any conflict resolved by revisiting the journal in question. Data synthesis: A descriptive analysis of the data was performed. No formal meta-analysis was carried out due to the substantial heterogeneity between the studies. Conclusions: Monoclonal antibodies, especially tocilizumab and eculizumab hold some promise in the treatment of the disease but controlled clinical trials using them as monotherapy are needed to further evaluate this finding.