ABSTRACT
Alzheimer's disease presents a serious challenge to the international scientific community. There are millions of infected people around the world and the numbers are increasing dramatically because this disease has no cure and develops rapidly over time. It becomes important to detect the disease and recognize symptoms early. Prevention is more effective than treating a disease that comes through several common factors. This helps people because they are still able to make important decisions about taking care of and spending money on their health. Thus, identifying symptoms or detecting them very early, lifestyle and commonalities of patients helps prevent such a disease. Henceforward, risk factors play a major role in the development of the disease, such as genetic and vascular factors or disorders. Also psychosocial factors which may positively influence the pathogenesis and clinical manifestation of the disease. From this, we conclude that constantly activating the brain is very important, as education, learning, sports and recreation are among the busyness of life’s preoccupations.

ABSTRACT
Red ginger (Zingiber officinale var. rubrum) is one of the herbal plants that have been widely known by Indonesian for generations. This plant is easy to obtain and has various health benefits. Therefore, it is necessary to obtain information about the phytochemicals and their traditional uses. The search for information was carried out by studying literature from various sources such as official books, Google Scholar and Garba Digital References (GARUDA) in the 2011-2021 range. The results showed that red ginger plants contain chemical compounds in the form of gingerols, shogaols, homovanilyl alcohol, alkaloids, flavonoids, saponins, tannins, phenolics, steroids, triterpenoids, and essential oils. Red ginger is commonly used by the community as a cold medicine, as well as for indigestion, urine laxative, natural antioxidant, as an analgesic, and others. With the content of these compounds, red ginger is also reported to have antibacterial, anti-inflammatory and antiemetic activity.

ABSTRACT
Diabetes is a chronic metabolic disease characterized by raised levels of blood glucose, which over time leads to serious damage to the heart, blood vessels, eyes, kidneys, and nerves. α-amylase Plays a major role in the digestion of starch and glycogen. Thus, inhibitors of this enzyme delay the breakdown of carbohydrates in the small intestine, thereby diminishing postprandial blood glucose in the diabetic patient. In this study, a DPPH radical scavenging activity and computational approaches were employed to uncover the potential of Aframomum Melegueta phytochemicals against type two diabetes mellitus mainly by molecular docking, molecular dynamic simulation, MMPBSA and ADMET analysis. The results show that it has high antioxidant properties. Molecular docking indicates that laurifolin, genkwanin and gulunalactone have good binding scores of -9.9 kcal/mol, -8.9 kcal/mol and -8.2 kcal/mol, respectively. And have interacted with at least two of the catalytic triads of α-amylase; Asp 300, Glu 233 and Asp 197. Molecular dynamic simulation results show that all the compounds are stable at the active site of the enzyme. Furthermore, MMPBSA analysis revealed they bind strongly with the binding energy of -21.77± 1.03 Kcal/mol, -17.82 ± 0.84 Kcal/mol and 15.07± 0.26 Kcal/mol for laurifolin, genkwanin and galanolactone. ADMET analysis indicated that all the ligands are water-soluble, drug-like and safe. This study shows that A. Melegueta extract has antioxidant properties and possess phytochemicals that can be exploited for further anti-diabetic drug development.

ABSTRACT
Alzheimer's disease is a neurological disorder that causes the brain to gradually and irreversibly shrink, atrophy, and die. There is no successful treatment for Alzheimer's disease to this day that makes it necessary to reduce its occurrence rather than treat the disease after it has occurred. Therefore, it became necessary and priority to focus on preventing it and knowing the causes that lead to the deterioration of the brain after it was fully active and strong. Back in the early stages of brain development in which food plays an important role. The focus comes on the important elements and materials that increase intelligence, skills, brilliance of thinking and memory, which continue with the person throughout his life after feeding him with important functional elements and vitamins. It is noted that with the development and increase of processed and refined food items that have recently entered the human body, there has been a significant increase and acceleration in the incidence of Alzheimer's disease at alarming and frightening rates. It has become worth reconsidering what we eat and focusing on the right food and its goal as one of the factors affecting the health of brain cells. Therefore nutritional awareness has become essential and nutritional supplementation is essential for a certain age as a fighter and as a preventer before contracting the disease.

ABSTRACT
The choosing wisely initiative of the Adaa program, in collaboration with the Ministry of Health (MoH), Kingdom of Saudi Arabia, aimed to improve physician-patient interaction to plan their care while avoiding the unnecessary and inappropriate tests, treatments, and procedures that increase the cost while adding no benefit in the health-related outcome of the patient. Of the many avoidable treatment medications, the one noted and selected is the over and misuse of esomeprazole, a proton pump inhibitor (PPI), used for gastroesophageal reflux disease (GERD), gastric ulcers, etc. The drug is commonly prescribed in clinical practice in general and over-the-counter in specific. As the published literature reports major adverse events associated with the drug, there is a need for a controlled prescription in selected cases to avoid its overprescription. In compliance with the choosing wisely initiative of Adaa health, we surveyed a regional secondary care facility (Baish General Hospital) after a twelve-week rigorous health education program for physicians and patients and concluded a substantial reduction in the prescription of esomeprazole. The survey findings; indicate the beneficial effects of teaching programs on avoidable treatment options to opt for suitable alternatives which will be both productive and cost-effective.

ABSTRACT
In a natural way, wound healing is slow phenomenon and sometimes may become long lasting with a long clinical course there by causing constant liberation of inflammatory modulators that cause pain and redness. Wound healing begins at the time of injury and can vary in length depending on the severity of the wound. The wound healing process can be divided into three stages: the inflammatory stage, the growth stage, and finally the remodeling stage, which determines the strength and appearance of the healed tissue. In the present work an attempt had been made to evaluate wound healing potential of Simple ointment base B.P was applied on control group rats. Cipladine (Povidone-Iodine IP 5% w/w, Batch no. UZ300) ointment was applied on standard group rats. Ointments with different extracts concentrations i.e. 0.5% (w/w), 1% (w/w) and 2% (w/w) assimilated in simple ointment base were applied on test group rats, in each model.

ABSTRACT
The main objective of the present work to established the fingerprint profile of S.hispida using high performance thin layer chromatography (HPTLC) technique. Preliminary phytochemical screening was done and HPTLC studies were carried out. The scanning was performed using 'CAMAG' densitometer scanner 3V equipped with CATS3 software, at a wavelength of 400 and 254 nm using deuterium lamp.Preliminary phytochemical screening of the methanolic extract S.hispida showed the presence of alkaloids, carbohydrates, phenols, tannins, flavanoids, gums and mucilage. HPTLC finger printing of S.hispida methanolic extract showed best results in Toluene: Ethyl Acetate: Formic acid: 5:4:1 solvent system. After scanning and visualizing the plates in absorbance mode at 254nm, 366 nm and visible light range (400-600nm after spraying with anisaldehyde sulphuric acid reagent) best results were shown at 400nm. The Rf values ranged from 0.06 to 0.99. The result showed that out of 15 components, the component with Rf values 0.95, 0.82 were found to be more predominant as the percentage area is more with 28.85% and 12.91% respectively.