Abstract: Covid-19 pandemic has a great psychosocial impact on society, due to fear of infection and disturbed the economy of the people. The aim of the study is to assess the psychosocial and economic impact of Covid-19 pandemic among sanitation workers of a tertiary care hospital. A cross sectional study was carried out from August 2020 to September 2020 at Kurnool Medical College, Kurnool. In previous studies, 75% of study subjects responded that Covid-19 has a serious psychosocial and economic impact. Considering prevalence of 75% and 20% of allowable error, sample size arrived at is 33.4, using the formula 4pq/l2. Out of 100 sanitation workers of one outsourcing agency, 30 workers who fulfilled inclusion criteria of one year work experience and with at least one school going child, were selected by simple random sampling. IEC clearance, permission from the work supervisor and informed consent from the study subjects was obtained. Data collected using a semi structured questionnaire was analysed using MS Excel-2016 version. Majority were in the age group of 31-40 years (63.33%). Most of them were females (90%), 50 % were literates. Decreased family income was noticed among 60% of study subjects and decrease in savings among 76.6%. 70% had fear of sickness and 73.33% responded that their children’s education was affected. Assurance of job security and social security measures at the work place would help these workers during such pandemics.