Introduction: The conversion from laparoscopic cholecystectomy to open cholecystectomy results in a significant change in out-come for the patient because of the higher rate of postoperative complications and the longer hospital stay in addition to the effect and the long-term sequel of the cause of conversion itself as in bile duct injury. Material and Methods: A prospective study was carried out in Department of Surgery, N.C Medical College and Hospital over a period of 1 year patients undergoing laparoscopic cholecystectomy. Full details of patients were recorded in the proforma. Out of 240 laparoscopic cholecystectomy performed during this duration 16 needed conversions. Result: Adhesions (85.7% versus 31.2%, P<0.001), bleeding (28.5% versus 8.7%, P<0.01), and stone spillage (28.5% versus 7.9%, p=0.04) were significantly more frequent in the conversion group. However, unclear anatomy, thick gall bladder wall, and bile spillage had no significant relationship with conversion of laparoscopic to open cholecystectomy. Conclusion: We found that a thickened gallbladder wall and a contracted gallbladder on ultrasound, male gender, age above 40, and acute cholecystitis were risk factors for conversion of laparoscopic cholecystectomy to open surgery.