Background: Treatment of brain tumors is in needed of combined efforts by multiple specialists from neurosurgery, neuroradiology, neuropathology, oncology and radiotherapy. The outcome is worse in developing countries compared to developed countries because of deficiencies in proper registry, lack of awareness, timely diagnosis, availability and co-ordination of multiple specialist’s comprehensive management and high abandonment rates. Aim of the study: The aim of this study was to assess the brain tumor spectrum of patient attending at a tertiary care hospital in Bangladesh. Materials and Methods: This observational prospective study was conducted in the Department of Radiology and Imaging, Enam Medical College & Hospital, Savar, Dhaka, Bangladesh during the period from January 2016 to December 2019. Ethical clearance was obtained from the mentioned hospital. In total 120 patients with brain tumors were finalized as the study population. The age of the participants was 20 years and above. Statistical analysis was performed using SPSS, version 20. Results: In this study male were dominating in number and the male-female ratio was 1.3:1. We found, the highest number participants 41-50 years, 31.67%(n=38) followed by 31-40 years of 27.50%(n=33) and 20-30 years of 17.50%(n=21). As clinical presentations, we observed, headache was associate in the highest number 59 in number, followed by seizure 41, vomiting 28, visual disturbances 9, gait disorder 7 and cranial nerve palsy were 4 participants respectively. In analyzing the spectrum of brain tumors we found, the frequencies of astrocytic tumor (42.50%), meningioma (14.17%) oligodendroglial tumor (10%) and embryonal tumor (7.50%) were noticeable besides other brain tumors. Conclusion: Males are dominating in number among the patients with brain tumors. Astrocytic tumors are most common subtype in Bangladesh. However, neoplasms of WHO grade 1 are more frequent brain tumors. Headache, seizure and vomiting are the most comm