EAS Publisher | A Prospective Study on Dexamethasone as an Analgesic Adjunct for Postcesarean Delivery Pain

A Prospective Study on Dexamethasone as an Analgesic Adjunct for Postcesarean Delivery Pain

DOI : https://doi.org/10.36349/easjacc.2021.v03i06.004

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Dexamethasone is a glucocorticoid medication used to treat rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, eye pain following eye surgery, superior vena cava syndrome (a complication of some forms of cancer), and along with antibiotics in tuberculosis. The major finding in this study was that for women who underwent cesarean delivery under spinal anesthesia that included intrathecal morphine, a single dose of dexamethasone 8 mg IV administered prior to skin incision did not reduce postoperative analgesic consumption or pain scores. Fifty women were enrolled and randomized to two groups of 25 patients. The median (IQR) opioid consumption in the first 24 hours after cesarean delivery was 12.5 mg (5-20 mg) in the dexamethasone group compared to 13.5 mg (5-22 mg) in the placebo group. The median difference in opioid consumption at 24 hours (94% CI) was -3 mg (-12.2 to 5.7) and was not significantly different between groups.

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