Background: Schizophrenia patients tend to have no life skills, leaving them dependent on their families. Caregivers in the form of family members improve patients' health status. On the other hand, schizophrenia also has a negative impact on caregivers. Therefore, this study aims to determine the factors that influence the quality of life in families with schizophrenia patients. Methods: A cross-sectional study was conducted online on December 31, 2021, for all families accompanying treatment at Aceh Mental Hospital. Furthermore, family members are directly involved in the care of schizophrenic patients living in the same household. Results: The results showed that 118 (55.9%) respondents were less than 40 years old, 161 (76.3%) were female, 119 (56.4%) had secondary education, and 162 (76.8%) were married. Furthermore, a total of 114 (54.0%) respondents have other jobs such as police, farmers, and others, 121 (57.3%) earn according to the minimum wage, 120 (56.9%) have high social support, 128 (60.7%) have a low family burden, 126 (59.7%) have a low family coping, and 112 (53.1%) have a low quality of life. Conclusion: Considering these results, there is a relationship between age, gender, family burden, coping strategies, income, and the life quality of families with schizophrenia at Aceh Mental Hospital. Furthermore, it was concluded that there is no relationship between marital status, social support work, and the life quality of the families.