Background: Platelet rich plasma therapy is a simple, low cost and minimally invasive method that provides a natural concentrate of autologous blood growth factors that can be used to enhance tissue regeneration (1). Recent evidences have shown that Platelet Rich Plasma Therapy can be helpful as an osteoarthritis (OA) therapeutic tool by intra-articular injection (2). Hyaluronic acid (HA) is widely used therapy for relief of OA pain and stiffness by intra-articular injection. In addition, there is a sufficient evidence for being significant disease modifying effects. Objectives: The aim of the study was to compare the clinical efficacy of Platelet Rich Plasma with that of hyaluronic acid viscous supplementation. Methods: This study included forty patients with hip osteoarthritis. These patients were selected from the Out Patient Department (OPD) of Dhaka Pain Management Center (DPMC) and Ava Pain & Intervention Center (APIC), Dhaka, Bangladesh during the period from January 2020 to December 2020. Patients were randomly divided into two groups. The first group consisted of 20 patients treated by using intra-articular injection of 2 ml autologous Platelet Rich Plasma Therapy. The second group consisted of 20 patients they were treated by using intra-articular injections of low molecular weight (hyaluronic acid [HA]) (32mg/2mL) of HA (HA group). All patients received 3 injections with one week interval (3) For Follow up: The subjective clinical outcome were measured at baseline, 1, 3, 6 and 12 months after the last treatment dose using the Visual Analog Scale (VAS) (5). Results: The Platelet rich plasma and Hyaluronic Acid groups showed an improvement, with significant difference between the two groups. However after 6 months follow up there was significant improvement in Platelet Rich Plasma Therapy group than HA group (P<0.005). The follow up after 12 months reveled subsided improvement than that was at 6 months. Nevertheless, this subsidence was less in Platelet ...