Introduction: Globally, an annual estimate of over 7 million deaths occurs due to Coronary Artery Disease (CAD) - the leading cause of Cardiovascular (CV) morbidity and mortality. Multivessel coronary artery disease (MVD) is defined as luminal stenosis of at least 70% in at least two major coronary arteries or in one coronary artery in addition to a 50% or greater stenosis of the left main trunk. Methods: A prospective observational study was carried out at Department Of Vascular Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from January to December 2021. Out of 286 individuals younger than 60 years old admitted to the outpatient clinic with chest pain and referred for coronary angiography were included in the study. All clinical and biochemical parameters were documented in the hospital records. Coronary angiography of patients was monitored from records. The individuals were divided into two groups. The patient group consisted of 182 individuals with at least one-vessel stenosis of ≥70%, and the control group consisted of 104 individuals with normal coronary angiography. We compared the traditional and nontraditional risk factors of these two groups in terms of the presence of CAD. Results: Prevalence of male sex and smoking were higher in the patient group, and the prevalence of hypertension and diabetes were similar in the two groups. In the patient group, mean age, blood cholesterols, serum gamma-glutamyl transferase, hemoglobin, and white blood cell and lymphocyte levels were higher, while estimated glomerular filtration rate (eGFR), high-density lipoprotein cholesterol (HDL-C), platelets, and neutrophil/lymphocyte and platelet/lymphocyte ratios were lower. Low eGFR and HDL-C levels, older age, male sex, smoking, and high levels of low-density lipoprotein cholesterol and lymphocytes were independent risk factors for the presence of CAD in young patients. Conclusion: In conclusion, contrary to studies done in the patients, ............