Aims: Diabetes leg ulcer is the ulceration of the leg associated with diabetes and in most cases result into amputation. Studies showed inadequate knowledge of the disease and this is why most of the patients only seek healthcare services after the Leg ulcer is already infected and seems not to be healing. Consequently, this study aims is to examine the effect of nurse-led education on knowledge of leg ulcer prevention. Materials and methods: A pre and post-test quasi experimental design was conducted with a multi-stage sampling technique to select forty participants through a convenient sampling method, and then allocated them into two groups by simple randomization (n=30 control, and n=30 experimental group). A modified structured questionnaire from preventive aspects of leg care practices used in America Diabetes Association and the National Diabetes Education were used to measure the knowledge level. Participants in experimental group were educated based on European Wound Management Association educational package. Data collected were analysed using frequency, mean, standard deviation, and independent paired t-test at 0.05 significant levels. Results: Result showed pre-intervention knowledge mean score of 5.2±2.3 and 5.1±2.0 with mean different of 0.1, while the Post-intervention knowledge means score of 12.5±3.2 and 5.4±2.6 with mean different of 7.1, in experimental and control respectively. Significant different was observed between the control and experimental group, after the intervention (t=11.82, ˂ 0.001). Conclusions: The nurses must provide a continuous and focused training program on leg ulcer for the diabetes patients to improve their knowledge on prevention of the diseases.