Background: One of the world's major health problems, preterm labor is characterized by significant perinatal mortality and morbidity. In one of these clinical situations, a healthy pregnancy might become one that is at high risk for both the mother and the fetus. Objective: To detect the risk factors and perinatal outcome in with complication in preterm labor. Materials and Methods: A case control study was carried out from February 2010 to July 2010 in the department of gynecology and obstetrics at the Dhaka Medical College Hospital. Results: A total of 50 instances of preterm labor occurring between 28 and 36 weeks of pregnancy and 50 control cases of lobour pain occurring between 37 and 40 weeks of pregnancy were screened and recruited in the research. The following risk variables were identified as being significantly linked with premature labor. Preterm delivery (OR -9.33), and Anaemia (OR = 8.31). Perinatal outcome in preterm lobour were Still birth, low APGAR score, neonatal resuscitation and neonatal complications significantly (p<0.05) higher in case group. Conclusion: The purpose should be to raise awareness of pregnant women who are at high risk for preterm labor since preterm labor has serious repercussions for both the mother and the infant.