The aim was to evaluate the epidemiological and clinical aspects and the main etiologies of the couple's infertility. Materials and methods: This was a descriptive, cross-sectional, randomized and analytical study with prospective data collection from April 1, 2020 to March 31, 2021, a period of 12 months at the Kalaban-Coro reference health center. Result: The infertility of the couple remains a major problem with a prevalence of 19.99% and a predominance of the majority of patients were 21-25 years old, a frequency of 27.8%. The majority of spouses were housewives (60.9%), merchants were the most represented among spouses with a frequency of 23.5%. Patients were married 100% of the time and 73.9% were without a co-wife. Secondary infertility was the most prevalent at 64.3%. Palms accounted for 28.7% and nulliparous 48.7%. The history was dominated by hypertension and caesarean section, i.e. 3.5% each. The desire to have a child was found as a reason for consultation in 83.5% of cases and the most represented duration for infertility was between 12-24 months in 57.4% of cases. The patient participation rate was 97.4%. Percentage for spouses it was 13%. Female etiologies accounted for 20.9% (tubal obstruction 7%, PCOS 5.2%, endometriosis 6.2%, polymyomatous uterus 2.6%, uterine synechia 1.7% and anovulation 0.9%) and male etiologies accounted for 46.67% (13.33% azoospermia, oligospermia and asthenospermia, 6.67% asthenospermia). Conclusion: The problem of infertility affects a growing number of couples. It concerns all social strata with a prevalence of 19.99% and a conception of the population that thinks that the etiology is feminine.