EAS Publisher | The Synthesis, Characterisation and Biological Evaluation of Novel Benzofuran Derivatives

The Synthesis, Characterisation and Biological Evaluation of Novel Benzofuran Derivatives

DOI : https://doi.org/10.36349/easjpp.2023.v05i05.003

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As Non-steroidal anti-inflammatory drugs plays a critical role in the management of multiple disorders, the demand of its existence in the clinical therapeutics is crucial. Hence, in this study synthesis, characterisation, and biological evaluation of novel benzofuran derivatives were performed. All synthesized compounds were purified by successive recrystallization from the appropriate solvents. The purity of compounds was checked by the TLC (thin layer chromatography). The characterization was done based on MP (melting point) determination and its properties was examined through TLC, FT-IR, 1H NMR, 13C NMR and mass spectroscopy. The anti-inflammatory activity of novel Benzofuran derivatives was estimated by rat paw oedema in vivo anti-inflammatory assay.

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Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

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