EAS Publisher | Hyperlipidemia: Mechanisms, Experimental Models, and Herbal Therapeutic Strategies

Hyperlipidemia: Mechanisms, Experimental Models, and Herbal Therapeutic Strategies – A Comprehensive Review

DOI : https://doi.org/10.36349/easjdom.2025.v07i03.001

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Abstract: Hyperlipidemia, characterized by elevated lipid levels in the blood, is a critical risk factor for cardiovascular, cerebrovascular, and peripheral vascular diseases. This review provides a comprehensive overview of hyperlipidemia, including its classification and lipid transport mechanisms. Various experimental models—diet-induced, genetic, and chemical—used to replicate hyperlipidemia in animals are discussed, highlighting their mechanisms and outcomes. Furthermore, the review explores the role of medicinal plants with antihyperlipidemic potential, including Cynara cardunculus, Medicago sativa, Allium sativum, Ginger, and Flax seeds. These herbs exhibit lipid-lowering effects via multiple mechanisms such as antioxidant activity, inhibition of lipid synthesis, and enhancement of cholesterol excretion. Their efficacy, often comparable to standard pharmaceuticals like statins, positions them as promising alternatives or adjuncts in hyperlipidemia management. The review underscores the potential of integrating traditional medicine with modern therapeutic approaches to combat hyperlipidemia effectively.

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Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

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