Background: Low back pain (LBP) is the fifth most common reason for hospital visits, which affects nearly 60-80% of people throughout their lifetime (Tillotson, 1995). The prevalence of low back pain is reported to be as high as 84%, and the prevalence of chronic low back pain is about 23%, with 11-12% of the population being disabled by low back pain (Koes, 2006). According to Damian (2014), In the 2010 Global Burden of Disease study the global age-standardised point prevalence of LBP (from 0 to 100 years of age) was estimated to be 9.4%. The same study showed that prevalence in 2010 was highest in Western Europe followed by North Africa/Middle East, and lowest in the Caribbean followed by central Latin America. Aim: The purpose of this study is to ascertain the level of tumour necrosis factor, physical activity and body adiposity in patients with non-specific chronic low back pain in relation to their apparently healthy counterparts between the age of 30 to 60 years in River’s state. Methodology: This is a quasi-experiment / cross sectional research design. Those that agreed to participate were included and they were selected randomly. All Patients with Non-specific chronic low back pain within the ages of 30 - 60, that complained of pain within 6 months, without any history of spinal decompression, non-pregnant women who presented with low back pain, who presented for treatment at the hospital participated in the study for the period of 6 months. Subjects with a history of heart disease, hypertension, diabetes, Pott’s disease, and use of drugs like steroids and pregnant women was excluded from the study because the cause of their back pain is known. Also, some of their back pain is temporary. They were of 2 groups. First group are the patients diagnosed of non-specific chronic low back pain and the second group are the apparently healthy individuals that serve as control. Their blood samples were taken by the lab scientist. and sent for analysis.