Background: Several efforts have been made to improve the quality of life of diabetic patients, but obtaining information about the most pressing problems in them may help direct the focus of the interventions. Aim: Was to discover the most worrying disturbances pertaining to diabetes and their relationship with depression in the lives of people living with diabetes mellitus type 2. Method: It was a cross-sectional study of consecutive attendees of diabetes mellitus patients who came for their routine check-up at the out-patient department of Enugu State University Teaching Hospital Enugu, Nigeria. Data were obtained from a clinical and sociodemographic questionnaire; the patient`s folder; General Health Questionnaire-9 (GHQ-9) to assess for depression; and response to an open-ended question: `What worries you most since you have been suffering diabetes mellitus`? Chi-square test was used to assess for association between depression and different disturbances of diabetes mellitus. Result: The rate of occurrence of depression among the participants was 28(16.7%). Most expressed worries about Diabetes were: somatic symptoms 72 (42.9%); treatment related problems (26.2%); poor health status (25.6%); poor finances (19.1%), but only the presence of somatic symptoms (P = 0.021) and poor health status (P = 0.001) have statistically significant association with depression. Conclusion: More attention should be paid to diabetic patients complaining about somatic symptoms and deteriorating poor health status, and it may be necessary to screen them for depression.