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Dia Smart Advantage: A Clinical Trial on Gummies/Candies for Diabetic Oral Wellbeing

DOI : https://doi.org/10.36344/ccijmb.2025.v07i04.004
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Background: Diabetes mellitus is closely associated with a variety of oral complications, including periodontal disease, xerostomia, candidiasis, and delayed wound healing. Conventional management is often fragmented and poorly adhered to. This study evaluates the effectiveness of HETAFU Dia Smart gummies/Candies—a chewable supplement containing probiotics, essential oils, and micronutrients—as an adjunctive therapy for oral disease management in diabetic individuals. Methods: A total of 240 diabetic patients were enrolled and randomly assigned to 16 clusters (15 participants per cluster). Eight clusters received standard care (control), and eight received HETAFU Dia Smart gummies/Candies along with standard care (intervention). Clinical parameters were evaluated pre- and post-intervention across eight oral health domains: periodontal health, burning mouth syndrome, oral infections, mucosal lesions, salivary dysfunction, taste disturbance, post-endodontic pain, and wound healing. Outcomes included Gingival Index (GI), Plaque Index (PI), Clinical Attachment Loss (CAL), VAS scores, salivary flow rate, healing duration, and lesion measurements. Results: Post-intervention data revealed statistically significant improvements in the intervention group across all clusters. Notable reductions were observed in GI (1.07 ± 0.25 vs. 1.88 ± 0.56; p ≤ 0.001), PI (1.06 ± 0.28 vs. 1.70 ± 0.44; p ≤ 0.001), VAS for burning mouth (1.33 ± 1.18 vs. 5.20 ± 1.61; p ≤ 0.001), and thrush area (2.13 ± 1.24 mm² vs. 9.93 ± 3.58 mm²; p ≤ 0.001). Salivary flow increased (0.57 ± 0.14 vs. 0.33 ± 0.13 ml/min; p ≤ 0.001), and healing time reduced significantly (5.07 ± 1.98 vs. 9.13 ± 2.50 days; p ≤ 0.001). Conclusion: HETAFU Dia Smart gummies/Candies demonstrated significant adjunctive benefits in improving oral health outcomes among diabetic patients. Their easy-to-consume format, combined with multifactorial bioactive action, makes them a promising complementary approach in the integrated manageme

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Dr. Afroza Begum

Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

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