Background: Violence against nurses in the workplace (WPV) is a rising public health problem, and this is particularly pronounced in rural areas with scarce healthcare resources and law enforcement. Background Osmanabad, as a district in the Maharashtra state of India, has specific vulnerabilities arising due to a lack of staff in the hospitals, sociocultural prejudices, and the high number of treatment seekers. Events of violence against such relatively small, young populations, predominantly female Staff, can also be taken to mean that they face an increasing risk of verbal abuse, physical aggression, and psychological harm. Objectives: This study was conducted to estimate the extent and nature of WPV against nurses practicing in Osmanabad; to identify structural and interpersonal contributors of workplace violence against nurses; to examine reporting practices and institutional responses; and to suggest culturally sensitive intervention strategies targeting this type of violence in such a rural setting. Methods: Design: Descriptive cross-sectional mixed-method studies with a combination of quantitative and qualitative data collection were used. Seventy registered nurses were purposively sampled and surveyed through structured questionnaires, and 12 were involved in semi-structured interviews. Quantitative data was analysed in SPSS version 23.0, and qualitative analysis of the interviews was performed with the software NVivo. The study received ethical approvals, and informed consent was acquired before data collection commenced. Results: Verbal abuse was experienced by 68.6% of the nurses, and physical assault by 12.9%. Alarmingly, 72.8% of experiences of violence were not reported, many were silenced by the fear of revenge, and the view that violence is an acceptable practice. The ED was the location for almost half of the WPV cases. Nurses reported large psychological effects with emotional exhaustion (47.1%) and anxiety (41.4%). There was low institutional rea