Background: The opioid crisis in the United States continues to escalate, with over 80,000 opioid-related deaths annually, many involving synthetic opioids like fentanyl. Dentists, particularly general practitioners, historically contributed significantly to opioid prescribing, often serving as a point of first exposure to opioids for adolescents and young adults. Objective: This review explores the evolving role of general dentists in the context of the opioid epidemic, analyzing their responsibilities, current prescribing practices, and potential contributions to mitigating misuse through evidence-based interventions. Methods: A narrative review of current literature, public health guidelines, and policy frameworks was conducted to assess the contribution of dental prescribing to opioid misuse and to identify best practices in pain management, education, and policy compliance. Results: While opioid prescriptions by dentists have declined, inappropriate and excessive prescribing remains prevalent. Evidence supports the efficacy of non-opioid analgesics, such as ibuprofen and acetaminophen combinations, as first-line therapy for most dental pain. National guidelines, including those from the ADA and CDC, advocate limited opioid use, implementation of Prescription Drug Monitoring Programs (PDMPs), and enhanced provider education. Patient counseling and expectation management also play a vital role in reducing misuse. Conclusion: General dentists are uniquely positioned to influence opioid prescribing practices. By embracing non-opioid alternatives, adhering to clinical guidelines, and engaging in ongoing education and patient communication, dentists can significantly reduce the risk of opioid misuse while ensuring effective pain management. A multidisciplinary, evidence-based approach is essential to positioning dentistry as a proactive force in addressing the opioid epidemic.