EAS Publisher | Hemophagocytosis in Acute Monoblastic Leukemia with a Complex Karyotype: A Case Report

Hemophagocytosis in Acute Monoblastic Leukemia with a Complex Karyotype: A Case Report

DOI : https://doi.org/10.36344/ccijmb.2025.v07i05.002

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Hemophagocytosis is a rare feature in leukemic blasts, occurring in approximately 1% of acute myeloid leukemias (AML), mainly in the monoblastic or monocytic subtypes [1,2]. Associations with chromosomal abnormalities, particularly t(8;16), have been reported, and the presence of hemophagocytic blasts can help suggest such cytogenetic alterations [2]. Unlike macrophage activation syndrome (MAS), no specific treatment is usually indicated for patients presenting hemophagocytic blasts [3]. We report a rare case of hemophagocytosis occurring in acute monoblastic leukemia with a complex karyotype associated with a poor prognosis according to the European LeukemiaNet (ELN) 2022 risk classification [4]. The clinical course was complicated by disseminated intravascular coagulation (DIC), and the patient died on the fourth day of induction therapy, emphasizing the adverse nature of this entity.

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Distinguished Professor of Haematology Head — Experimental, Historical & Sensory Haematology Vlad the Impaler University, Wolf’s Lane, Wooden Stakes Grove 666, Transylvania.

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