EAS Publisher | Effects of CPDA-1, ACD and Heparin Anticoagulants on the Quality of Canine Whole Blood during Storage

Effects of CPDA-1, ACD and Heparin Anticoagulants on the Quality of Canine Whole Blood during Storage

DOI : https://doi.org/10.36349/easjvms.2025.v07i03.001

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This study was conducted to compare the effects of three common anticoagulants (CPDA-1, ACD, and Heparin) on the quality of canine whole blood during 21 days of storage at 4 °C. A total of 90 blood samples from eligible dog donors were randomly divided into three experimental treatments using anticoagulants CPDA-1, ACD and Heparin, respectively. Hematological parameters were periodically analyzed on days 0, 1, 3, 7, 14, and 21. The results showed that CPDA-1 was the superior anticoagulant, best maintaining the stability of red blood cell parameters (RBC, HGB, HCT, MCV) while significantly slowing the decline in white blood cell (WBC) and platelet (PLT) counts. In contrast, Heparin demonstrated the poorest preservation efficacy, causing a severe deterioration in red blood cell quality and an almost complete loss of platelet function; while ACD yield intermediate results. These changes are characteristic manifestations of "storage lesions." Therefore, this study confirms that CPDA-1 is the primary choice for the long-term storage of canine blood in veterinary blood banking practice.

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