A 63-day study was conducted to determine the effect of the extruded feed enriched with garlic and ginger on the growth performances, whole body composition, and organosomatic indices of red tilapia fingerlings raised in a concrete tank. The 1,320 mixed-sex red tilapia fingerlings, weighing 4.77±0.14g were randomly allocated in triplicate in 12 hapas corresponding to four treatments. Treatment T0 (control) received the basal diet, while the fingerlings in treatments T1, T2, and T3 were fed the basal diet enriched with 1.5% garlic, 1.5% ginger, and 1.5% garlic-ginger mixture, respectively. Feeding took place four times a day at a rate of 5–4% of the biomass, with intermediate sampling occurring every three weeks for biometric assessments and total fish counts. The results indicate that all the parameters assessed were significantly improved in red tilapia fingerlings fed the experimental diets compared to the control. However, the best performances were obtained in fish fed the diet enriched with garlic powder with a weight gain (64.96±4.88g), specific growth rate (2.71±0.28%/d), protein efficiency ratio (2.85±0.30), and feed conversion ratio (0.97±0.10) significantly different from 26.22%, 33.95%, 25.26%, and 20.49% compared to control. For the body composition, the same observations were made regarding the contents in protein, lipid, ash, and energy, with a significantly higher impact on the body retention of the aforementioned nutrients, justifying thereby the best growth and welfare state of the gastrointestinal organs of the produced fish in treatment T1 compared to other treatments, particularly the control treatment.