Doxorubicin (DOX) is a potent chemotherapeutic agent widely used for treating various cancers, but is known for its detrimental side effects, including reproductive toxicity in males. The aim of this study to the effects of hydroethanol extracts of tiger nuts (Cyperus esculentus) and date palm (Phoenix dactylifera) against Doxorubicin (DOX) induced reproductive damage in male Wistar rats. A total of 35 rats were divided into seven groups with 5 rats per group and subjected to DOX-induced reproductive toxicity (15 mg/kg for three days), followed by administration of different doses of the plant extracts, for 27 days. On the 31st day animals were sacrificed and samples collected for the Biochemical analysis of reproductive hormone levels (FSH, LH, testosterone), sperm quality, and testicular histology. The DOX-only group showed significant reductions in sperm count, motility, hormone levels, and antioxidant status, with increased lipid peroxidation and abnormal testicular histology. Conversely, groups treated with tiger nuts and date palm extracts, particularly at high doses and in combination, demonstrated marked improvements in these parameters. Co-administration significantly restored hormone levels, enhanced antioxidant enzyme activity, improved sperm morphology and count, and reversed DOX-induced histopathological alterations. The findings confirm that tiger nuts and date palm possess strong antioxidant and fertility-enhancing properties capable of mitigating DOX-induced reproductive toxicity.