Objective: To study the epidemiological and clinical aspects of stroke. Methodology: A one-year prospective descriptive study conducted at the Gabriel Touré University Hospital Emergency Department on patients diagnosed with stroke. The tools used were SPSS 22.0, Microsoft Word 2021 and Excel software. The Chi-square test is significant if P is ˂0.05. The information was collected anonymously and confidentially. Results: out of 20,001 admissions to the emergency department, 751 patients were diagnosed with stroke (3.7%). The average age was 61.7± 17.5 years, with a sex ratio of 1.39. The majority were traders (33.4%) and lived in urban areas (77%). Transport was provided by taxis (66.7%), with an average time of 11.9±4.9 hours. The most common medical history was high blood pressure (89.5%). Impaired consciousness was the most common reason for consultation (69%). Hemiplegia was the most common clinical sign (46.2%). The Glasgow score on admission was between 13-15 (44.1%) and Glasgow less than 8 (15%). MAP was 160±45 mmHg for IS and 140±35 mmHg for SAH. DTC was performed (40%), confirming ICH (34%). Strokes were ischaemic (56.1%) and haemorrhagic (33.3%). Secondary cerebral attacks of systemic origin were hyperthermia (55%) and hyponatraemia (30%). Complications were pulmonary (50%) and neurological (26.6%). Treatment was medical (75%) and medico-surgical (25%), with systematic rehydration and prevention of stress ulcers. Mortality was 41.2%, with an average hospital stay of 8.1± 6.5 days. Conclusion: Strokes remain a major public health concern. Improving prognosis requires early pre-hospital care with multidisciplinary collaboration and adequate technical facilities.