Objective: To report on the experience of the anesthesia-intensive care unit of the Conakry University Hospital concerning the practice of ultrasound-guided peripheral nerve blocks (PBB). Methods: This was a descriptive retrospective study carried out over a period of 24 months, from October 2022 to September 2024, in the operating room of the University Hospital of Conakry. We included all records of patients aged 18 years and older, who received ultrasound-guided BNP for scheduled or emergency surgery and gave informed consent to participate in the study. Results: The frequency of peripheral blocks was 8.7%. The average age of the patients was 40 years, with a predominance of women (60%). The operating rooms were mainly performed for patients in the traumatology-orthopedics department (34.3%). The most frequent operative indication was fracture of the two bones of the forearm (26.2%). ASA Class I was the most represented (74.8%). The average duration of the blocks was 10 ± 1.8 minutes. Analgesic blocks predominated (63.1%), followed by anesthetic blocks (36.8%). TAP block (33.1%) and axillary block (27.5%) were the most common. Bupivacaine 0.25% was the most commonly used anesthetic (47.3%), followed by Xylocaine adrenalin (34.1%). Conclusion: Although recent in Guinea, the practice of ultrasound-guided NPPs offers promising potential, particularly in traumatology-orthopedics. Their development requires increased investment in equipment and training to maximize their benefits.