The sesame web worm (Antigastra catalaunalis) is the most important and serious pest attacking sesame in its early stages. It feeds on tender foliage by webbing the top leaves and bores into the capsules thus feeds in the internal contents. The objective of this study was to study the’ Susceptibility of Sesame varieties and performance of plant extracts (neem powder, garlic powder, and insecticide Escort 19EC against sesame webworm (Antigastra catalaunalis) (lepdidoptera: pyralidae) on sesame production. The field experiment was established at the Gaheyr experimental field of Faculty of Agriculture and Environmental Science, Somali National University, Mogadishu, Somalia. The trial was laid out in a Randomized Complete Block Design (RCBD), featuring three replications with eight distinct treatments. This study evaluated the susceptibility of two sesame varieties—the local Somali 'Dunyar' and the Ethiopian 'Humera'—to webworm infestation. The trial included both treated and untreated (control) groups for each variety. To quantify infestation, five plants were randomly selected from each plot, and the percentage of infested plants was recorded. The result of this study indicates that the Treated varieties with Escort 19EC And Neem was less infested and the reduction of pest infestation was observed. The infestation percentage of all treatments before spray was recoded a similar percentage i.e. (100%) of infestation. However, the measured infestation after first spray relatively reduced into 30% at the treatment of Humera treated with Escort 19EC, and 40% for the treatment of local white treated with same insecticides thus insecticide Escort 19EC showed a great significant of the reduction of the Sesame webworm infestation. The study also briefly indicates that other treatments, neem powder, and garlic done slighter reduction on the infestation of the sesame webworm (Antigastra catalaunalis).