EAS Publisher | Topical 5-Fluorouracil as an Adjunct to Enucleation in the Management of Odontogenic Keratocyst

Topical 5-Fluorouracil as an Adjunct to Enucleation in the Management of Odontogenic Keratocyst

DOI : https://doi.org/10.36349/easjdom.2025.v07i06.003

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The odontogenic keratocyst (OKC) accounts for approximately 3% to 11% of all odontogenic cysts and is characterized by aggressive behavior, significant growth potential, and a high recurrence rate, prompting the exploration of more effective and conservative adjuvant therapies. This report describes the clinical management of a case treated with surgical enucleation and topical application of 5-fluorouracil (5-FU), an antimetabolite widely used in oncology and dermatology, whose application has been extrapolated to the treatment of OKCs due to molecular similarities in their pathophysiology. A 66-year-old female patient with an odontogenic keratocyst in the right mandibular ramus was treated by enucleation and placement of a gauze dressing impregnated with 5% 5-FU. After 15 months of clinical and radiographic follow-up, a favorable outcome was observed, with adequate bone regeneration and no evidence of recurrence. This case adds to the growing body of evidence supporting the use of 5-FU as an effective, minimally invasive therapeutic alternative for odontogenic keratocysts.

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