Background: Inflammation denotes the body's standard physiological response to tissue damage. The injury may stem from physical or mechanical damage, trauma, autoimmune response, microbial invasion, or burns. Inflammation may be classified as either acute or chronic. Ziziphus jujube (ZJ), also known as Chinese date or Indian ber, is a widely researched medicinal plant due to its abundant phytochemical content, which may promote a healthy diet. It is a medium-sized indigenous plant belonging to the Rhamnaceae family. Ziziphus jujube (Z. jujube) is traditionally employed by locals to address dandruff, arthritis, chronic constipation, acne, antibacterial concerns, and cardiac ailments. Jujube comprises several constituents, such as flavonoids, triterpenic acids, amino acids, cerebrosides, mineral elements, phenolic acids, and polysaccharides. Aim: This study seeks to examine the effectiveness of Ziziphus jujuba flavonoid and terpenoid against COX-2 & 12- LOX to clarify their anti-inflammatory potential. Method: COX-2 & 12- LOX was chosen as the target proteins in the current investigation. The bond was found using the Auto Dock software using a grid-based docking method. Compounds' 2D structures were generated, converted to 3D, and subsequently energetically lowered up to an arms gradient of 0.01 using the Merck Molecular Force Field (MMFF). Result: Flavonoids (isoquercetrin) and terpenoid (zizyberanolic acid) of Z.jujuba effectively binds to be target protein COX-2 & 12-LOX respectively with binding energy -5.46 & -5.95 kcalmol-1 respectively. Conclusion: The finding of the in-silico molecular docking showed that both lead compound is effective binds & inhibitory action on target protein. The molecular docking outcome revealed that isoquercetrin binds COX2 whereas zizyberanolic acid binds 12-LOX, thereby suppressed the synthesis of PGs and ILs.