Introduction: Nigeria is among the hot spot of Mycobacterium tuberculosis in the world. This massive increase is due to the improved case detection capacity and enhanced surveillance systems with stronger diagnostic infrastructure. We aimed to determine the trends of Mycobacterium tuberculosis in Niger State, Nigeria. Materials and Method: This is a retrospective study. The study population is the notified cases of TB in Niger State of the Year 2014-2024. All forms of TB; pulmonary and extrapulmonary, drug-susceptible, drug-resistant TB, and HIV co-infection were included. Statistical analysis was conducted under STATA version 17.0 for standard statistical analysis, R version 4.3.0 for complex modeling, NVivo version 14.0 for qualitative analysis, REDCap for questionnaire data management, and ArcGIS for geographic analysis. Result: Based on our data, notified cases tracked in the study area increased from 1,532 in 2014 to 10,907 in 2024, indicating good reporting procedures and case registration systems. There was a consistent rise in both new TB and notified cases. The massive increase in new cases by 991%, from 1,044 cases in 2014 to 10,341 cases in 2024, which represents an average annual increase of approximately 927 cases. Surprisingly, TB cases rose by 991%, but mortality by 92%, mirroring gigantic improvements in case fatality and stupendous developments in the effectiveness of treatment. Despite the increase in TB notifications, TB-related mortality in Niger State remained relatively stable throughout the study period. This pattern aligns with national reports showing improved TB treatment outcome. Conclusion: The trends of Mycobacterium tuberculosis in the study area suggests improved diagnostic and treatments accessibility.