EAS Publisher | An Experimental Design Approach for the Optimization of Hesperidin Extraction from Orangette

An Experimental Design Approach for the Optimization of Hesperidin Extraction from Orangette

DOI : https://doi.org/10.36349/easjals.2026.v09i02.001

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The aim of this work is to study the development of a response surface methodology for the optimization of hesperidin extraction from orangette composition. The optimization of extraction parameters such as concentration, pH, temperature and extraction time were performed by the centered composite design (CCD) method. The analysis of variance showed a good fit of the model and the performance of the RSM method to improve hesperidin extraction, due to the fact that R2=0.927, R2Adjusted=0.825, R2Pred=0.602 and P<0.05. The optimal conditions determined for the extraction of hesperidin by the response surface methodology were 130 mg/ml for the solvent concentration, pH (12.67), temperature (62°C) and extraction time 3.45h for the extraction time with a theoretical yield is 67.44%. These results showed that the developed model is satisfactory and relevant for hesperidin extraction.

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