Speedboat drivers are known to operate daily under challenging conditions, including prolonged engine vibration, exposure to fuel fumes, amongst others; thus, making it necessary to assess the likely adjustments in the cardiopulmonary profile possibly exerted by these occupational exposures. This cross-sectional observational study was conducted amongst speed boat drivers operating in Port Harcourt, Rivers State, Nigeria. The study used the purposive/snowball sample size techniques to recruit the participants. Precisely 60 consenting subjects were engaged in the study, making up 30 speedboat drivers and 30 non- speedboat drivers. Quantitative data obtained from the study participants were statistically analysed using version 25.0 of the IBM Statistical Product and Service Solutions (SPSS) software. The study found that, the boat drivers were within their productive age (44.60 years) with healthy mean BMI (26.00 ± 9.28 Kg.m2). On changes in cardiovascular indices, the study found significantly (p<0.05) raised systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure levels in the speed boat drivers with higher risks of hypertension. Considering the outcome on electrocardiographic (ECG) changes in the speedboat drivers, it was found that there was a comparatively lower incidences of sinus rhythm with normal ECG features but raised abnormal ECG features. The speed boat drivers also manifested sinus arrhythmia, septal infarct, sinus bradycardia, and many cases of sinus rhythm with abnormal findings. It is thus suggested that, the subjects should be educated or motivated to have good health-seeking attitude in order to avert possible risks of cardiovascular accidents.