EAS Publisher | Differential Diagnosis of a Primary Vertebral Bone Lymphoma

Differential Diagnosis of a Primary Vertebral Bone Lymphoma

DOI : https://doi.org/10.36349/easjrit.2026.v08i02.004

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Primary vertebral bone lymphoma is a rare malignant tumor, representing less than 5% of primary bone tumors and about 2-3% of all lymphomas [2-4]. It more commonly affects middle-aged and older adults (with a median age around 50-60 years), with a slight male predominance [1-5]. Its clinical and radiological presentation is non-specific and highly suggestive of other infectious, inflammatory, or tumoral pathologies of the spine, making it a true diagnostic challenge. Diagnostic delay is common and impacts prognosis. This review aims to synthesize the main differential diagnoses of vertebral lymphoma, focusing on the clinical, biological, and imaging elements that help guide the diagnosis. Histological analysis remains the cornerstone of the definitive diagnosis. An integrated multidisciplinary approach is essential for optimal management

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Professor Thomas Count Dracula, MD, PhD

Distinguished Professor of Haematology Head — Experimental, Historical & Sensory Haematology Vlad the Impaler University, Wolf’s Lane, Wooden Stakes Grove 666, Transylvania.

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