Breast cancer remains one of the leading causes of morbidity and mortality among women worldwide, and early detection through breast self-examination (BSE) has proven to be an effective preventive measure. This study examined the attitudes and practices of breast self-examination among female undergraduates in Emuoha Local Government Area, Rivers State, Nigeria. The objectives were to assess the level of awareness, attitude, and frequency of BSE practice, and to identify factors influencing students’ participation in the exercise. A descriptive cross-sectional survey design was adopted. A structured questionnaire was administered to a sample of female undergraduate students selected through simple random sampling. Data were analyzed using descriptive statistics such as frequency counts, percentages, and means, and the results were presented in tables. The findings revealed that although most respondents had adequate awareness and positive attitudes toward BSE, only a small proportion practiced it regularly and correctly. Major barriers identified included forgetfulness, lack of knowledge of proper technique, fear of detecting a lump, and negligence. The study further found that students in higher levels of study demonstrated better knowledge and practice compared to those in lower levels, suggesting the influence of educational exposure. Despite their awareness of breast cancer risks and the importance of early detection, many respondents had not integrated BSE into their regular health routines. The study concluded that while awareness and attitudes toward BSE among female undergraduates are encouraging, actual practice remains low. It recommends continuous health education, practical demonstrations, inclusion of breast health in university orientation programs, and the use of peer and media-based interventions to promote consistent practice. Strengthening these strategies will enhance early detection of breast abnormalities and contribute to reducing breast cancer