The article has three primary sections. The first section deals with the recent application of the Indigo dye. The second section deals with the reviews of the drug from multiple angles. The third section deals with the application of Indigo in dentistry & Homoeopathy. The article traces the history of Indigo not only in medicine but also in agriculture, horticulture, crops, plantation, economics, culture, arts, social science, rural economy, Ayurveda, Homoeopathy, dentistry & Microbiology. However, it touches upon all other subjects & deal in partial detail in the field of dentistry. Only Homoeopathy is the area that is touched upon in detail in the article. Indigo cuts across times across the globe as its use are multifaceted. The curiosity across era regarding Indigo just shows its importance especially in our country. Besides the synthetic use, it is good to know that the natural use of Indigo is on the rising trend. The natural use of Indigo has one of its tentacles in its Homoeopathic dimension. It is a broad spectrum drug in Homoeopathy that is used for various uses. The various systems of the human body that benefit from the use of Indigo in Homoeopathy are the Central Nervous System (CNS), Gastro Intestinal System (GIS), Excretory System, Musculoskeletal System & Cardio Vascular System (CVS).