Background: Obstetric emergencies represent a leading cause of maternal and fetal morbidity and mortality worldwide, particularly in sub-Saharan Africa. Data from northern Cameroon remain scarce, motivating the present study. Objective: To describe the epidemiological, clinical, therapeutic, and prognostic profile of third-trimester obstetric emergencies at the Garoua Regional Hospital (GRH), Cameroon. Methods: A descriptive cross-sectional study with retrospective data collection was conducted in the Gynecology-Obstetrics department of the GRH from January 1 to December 31, 2023. All pregnant women in the third trimester or in the immediate postpartum period with a confirmed obstetric emergency were included. Data were analyzed using IBM SPSS version 23.0. Results: A total of 336 obstetric emergencies were recorded out of 2,557 pregnant women (frequency: 13.14%). The mean age was 25.30 ± 6.68 years. The most common emergencies were dystocia (36.6%), hemorrhagic emergencies (30.9%), acute fetal distress (29.7%), hypertensive emergencies (22.7%), and infectious emergencies (6.3%). Surgical treatment was performed in 68.5% of cases. Maternal mortality was 3.7% and fetal/neonatal mortality was 25.5%. Conclusion: Third-trimester obstetric emergencies are frequent at the GRH. Dystocia, hemorrhage, and acute fetal distress are the leading types. Fetal/neonatal lethality remains high, underscoring the need for strengthened antenatal care and emergency obstetric services in this region.