This study undertakes a comprehensive investigation into the phytochemical profile and potential dye properties of Cola acuminata extracts obtained using a range of solvents, including methanol (MeOH), ethyl acetate (EtOAc), and hexane (n-hexane). Phytochemical screening revealed a diverse array of bioactive compounds, with the MeOH extract exhibiting high levels of phenolic compounds, flavonoids, and tannins, underscoring its efficacy in extracting polar phytochemicals. The MeOH extract demonstrated superior antioxidant activity across multiple in vitro assays, including the hydroxyl radical scavenging assay (HRSA), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, with inhibition percentages of 57.43%, 65.59%, and 62.88%, respectively. The estimated IC50 values for the HRSA and DPPH assays were approximately 300 µg/mL, indicating that higher concentrations are required to achieve significant antioxidant activity relative to the positive control, butylated hydroxytoluene (BHT), which exhibited a maximum inhibition of 75.25%. The EtOAc extract was found to be rich in terpenoids and quinones, suggesting its potential for extracting semi-polar compounds with putative antimicrobial properties. The n-hexane extract contained notable amounts of phenolic compounds and tannins, albeit with a lower overall phytochemical diversity. The presence of alkaloids in all extracts highlights their biological significance, including potential anti-inflammatory and antimicrobial activities. The findings of this study underscore the potential of Cola acuminata as a valuable source of natural dye and bioactive compounds with applications in the pharmaceutical and leather tanning industries. Future research directions should focus on the application and characterization of specific phytochemicals responsible for coloring activities, as well as elucidating their action on leather during tanning process.