Takotsubo syndrome (TTS) is an acute reversible cardiomyopathy mimicking acute coronary syndrome (ACS), characterized by transient left ventricular dysfunction. It usually occurs after intense emotional or physical stress. Few cases of TSS in a perioperative setting have been described in the literature. However, recent literature data show an increase in its incidence in the perioperative period in recent years. The prognosis is generally favorable, but the outcome can often be rapidly fatal. We report a case of Takotsubo syndrome that occurred immediately after surgery in a 55-year-old patient with chronic coronary artery disease who underwent right middle lobectomy with lymph node dissection. The event was triggered by an episode of severe hypoxia and an injection of adrenaline. The diagnosis was confirmed by echocardiography (LVEF 25%, circumferential apical akinesis) and coronary angiography (chronic bifocal stenosis without acute occlusion). The outcome was favorable after symptomatic treatment and hemodynamic suppor, with complete recovery of left ventricular function. This observation illustrates the possibility of TST in a surgical setting in coronary patients. We also describe the diagnostic and therapeutic aspects of this rare perioperative complication.