Background: Cutaneous wound healing is a vital physiological process that involves the cooperation of several types of cells and their substances. The process of repairing the damage caused by a local injury starts at an early stage of inflammation. Ultimately, they lead to repair, which involves the replacement of specialized structures due to the deposition of collagen, and regeneration, which refers to the process of cell growth and subsequent differentiation from existing cells in the tissue and/or stem cells. Two These methods are not mutually exclusive. After a skin lesion, both regeneration and repair can occur in the same tissue, depending on the specific cell strains affected by the injury. Method: The present study aimed to identify protein inhibitors for glycogen synthase kinase-3 β (GSK-3 β) utilizing a molecular docking method. The binding was found using the Auto Dock software, which employed a grid-based docking approach. The 2D structures of compounds were created using the Merck Molecular Force Field (MMFF), which were then translated to 3D and energetically minimized with an arms gradient of 0.01. Results: The molecular docking analysis indicated that lupeol exhibited a highly favourable docking score. The docking score was determined to have a binding energy of -9.55 kcal/mol. Conclusion: The investigation's results showed that the lupeol had potent inhibitory action on GSK-3 β resulted in considerable wound healing efficacy.