Introduction: Many people easily access information about medications to treat their symptoms, despite not knowing the side effects of these drugs. One of the frequently used medication options is NSAIDs, such as Diclofenac Sodium. The irrational use of Diclofenac Sodium can cause side effects such as gastritis. Measures that can be taken to reduce inflammation and damage to the gastric mucosa are by administering medications and herbs. One of the herbal plants that can be used is Binahong Leaf. Aims: To identify the effect of Binahong Leaf extract on gastric histopathology of white rats induced by Diclofenac Sodium. Method: The research is a laboratory experiment with a true experimental design posttest only with control group approach in the treatment and control groups. The experimental animal samples were divided into 5 groups, namely the negative control, positive control, treatment 1 (extract dose 100 mg/kgBW), treatment 2 (extract dose 150 mg/kgBW), and treatment 3 (extract dose 200 mg/kgBW). Assessment of gastric mucosal epithelium using Barthel Manja Scoring. Data analysis using One Way Anova Test and Post Hoc Fisher's LSD Test. Results: The test results using One Way Anova showed a significant difference in the histopathology of the stomach of white rats given Binahong Leaf extract with a value of p = 0.000 (p <0.05). Conclusion: There is an effect of Binahong Leaf extract on gastric histopathology of white rats induced by Diclofenac Sodium with the most effective dose of 200 mg/ kgBW.