Background: Bacterial infections of the reproductive tract are a leading cause of morbidity among women of child bearing age globally. These infections can affect either the upper reproductive tract, encompassing the fallopian tubes, ovaries and uterus, or the lower reproductive tract, featuring the vagina, cervix and vulva. Objectives: The study aimed to determine the incidence of bacteria causing reproductive tract bacterial infections among women of reproductive age attending Homabay County teaching and referral hospital in Kenya and their current antibiotic susceptibility profiles. Materials and Methods: A cross- sectional study design was adopted, employing a systematic sampling technique. The minimum sample size was determined using Fisher et al.'s formula and sample analysis done at the Homabay County Teaching and referral hospital laboratory. High vaginal swabs were examined for bacterial vaginosis and grading performed using Nugent’s. All gonorrhoea isolates were tested for antibiotic sensitivity using the disc diffusion method with reference to CLSI 2024 guidelines. Data analysis employed Statistical package for social sciences version 28, with a significance level set at P ≤ 0.05. Fisher’s exact test was employed to assess the sensitivity of Neisseria gonorrhoea to various antibiotics commonly prescribed for treatment. Ethical approval was provided by the Kenyatta University Ethical Review Committee and research permit obtained from the National Commision for Science, Technology and Innovation. Results: Findings on reproductive tract infections among 360 women showed 20.3 % incidence. Neisseria gonorrhoea exhibited 100% resistance to tetracycline, 34% resistance to penicillin, and 100% sensitivity to ceftriaxone. Conclusions and Recommendations: Owing to the high incidence rate and poor sensitivity rates to most antibiotics, the study recommended regular screening of women of child bearing age for reproductive tract bacterial infections and prioritizing c