Background: Reproductive tract bacterial infections are a leading cause of morbidity among sexually active women worldwide. Female reproductive tract infections can affect either the upper reproductive tract, which includes the fallopian tubes, ovaries and uterus, or the lower reproductive tract, comprising the vagina, cervix and vulva. Objectives: The study aimed to determine reproductive tract bacterial infections and sexually transmitted infections among women of reproductive age attending Homabay County teaching and referral hospital in Kenya as well as the socio-demographic factors associated with these infections. Materials and Methods: A cross- sectional study design was adopted, employing a systematic sampling technique. The participants were interviewed using a structured questionnaire to obtain data on the socio-demographic factors. Blood and high vaginal swab samples were obtained from each participant for the analysis of bacterial infections. Sample analysis was done at the Homabay County Teaching and referral hospital laboratory, Kenya. Data analysis employed Statistical Package for Social Sciences version 28, with a significance level set at P ≤ 0.05. High vaginal swabs were examined for bacterial vaginosis and grading performed using Nugent’s criteria while blood samples were examined for Treponema pallidum. Results: Findings on reproductive tract bacterial infections among 360 women showed; 20.2% prevalence, with Bacterial vaginosis (BV) infections having 5.8% while for sexually transmitted infections: Treponema pallidum (10.8%) and Neisseria gonorrhoea (3.6%) were established. Conclusions and Recommendations: The study concluded that reproductive tract infections, as well as sexually transmitted infections driven by, T. pallidum and N. gonorrhoea, pose a public health challenge and recommended routine screening among women of reproductive age.