ABSTRACT
Permanent wearing of a removable prosthesis can be a source of mechanical irritation, which will lead to the appearance of pathological conditions. These conditions can be of several types but the most common are oral candidiasis with Candida albicans. As part of the scientific research, we have begun a practical study that aims to establish the relationship between the wearing of a removable denture and the colonization of the oral cavity by Candida albicans. This study was carried out in collaboration with the central laboratory of parasitology –mycology of the Ibn Sina University Hospital Center of Rabat (CHU) and assistant prosthesis department of the clinic of the Faculty of Dentistry of Rabat. The present study was carried out on 45 specimens from the oral cavity in subjects with a removable prosthesis. We observed that most subjects affected by oral candidiasis had inflammation in the oral cavity and these subjects did not have adequate oral hygiene. 30% of these subjects had chronic diseases and 20% of male subjects were smokers. Most subjects with prostheses older than 10 years were the most affected. Mycological examination of the samples made allowed us to note 35.5% of fungal infection by the genus Candida and 27% by the species Candida Albicans. C. albicans was the most isolated yeast representing 75% of the yeasts isolated in this study, followed by C. famata, after C.tropicalis with a lower frequency and finally C.dubluensis with the lowest frequency. We also observed a relationship between the nocturnal use of the prosthesis and the presence of Candida albicans, indeed most subjects affected by oral candidiasis kept their prostheses during the night.

ABSTRACT
Coronary artery disease (CAD) is the primary cause of myocardial infarction (MI), which is defined by a decreased or stopped blood supply to a portion of the heart myocardium, resulting in cardiac cell death. Because CAD robs the heart of oxygen supply, it frequently presents as silently or with symptoms like radiating chest pain to the shoulder, arm, neck, or jaw. Elevated cardiac troponins and ECG alterations are involved in the diagnosis. MI is caused by prolonged blockage of a major coronary artery; collateral circulation, hemodynamics, and residual blood flow all affect the size of the infarct. Atherosclerosis, thrombosis, and plaque erosion are the primary causes of ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI). Male pattern baldness, advancing age, a family history of the condition, high cholesterol, smoking, hypertension, diabetes, obesity, and stress are risk factors for MI. Aortic dissection, drug misuse, and anomalies in the heart are further causes. Anaerobic respiration and lactate buildup are the results of tissue oxygen deprivation, which starts both reversible and irreversible phases of Myocardial infarction. Oxidative stress and endothelial dysfunction, in conjunction with inflammation and susceptible plaques, worsen the development of MI. Significant MI risks are highlighted by epidemiological research on smoking, obesity, diabetes, hypertension, and socioeconomic variables. Other factors include family history and genetic predisposition. Given that MI continues to be a major cause of morbidity and death worldwide, an understanding of its pathophysiology and risk factors is essential for both prevention and intervention. To lessen the effects of this terrible illness, effective strategies require prompt intervention and thorough risk factor control.

ABSTRACT
Introduction: Pancytopenia is a fairly common hematological condition encountered in routine clinical practice. Since there is a wide variation in the etiologies of pancytopenia, even in different populations of the same geographical region, the identification of underlying etiologies is important. With this in mind, our study was undertaken to investigate the epidemiological and clinico-hematological profile of pancytopenic adults with the aim of identifying the different etiologies of pancytopenia. Materials and Methods: This is a retrospective study including all adult patients with pancytopenia admitted to the internal medicine department at Hassan II University Hospital in Fez, Morocco, from January 1, 2019 to December 31, 2022. Pancytopenia is defined by the simultaneous presence of a hemoglobin level < 13.0g/dL in men and 12.0g/dL in women, a total leukocyte count < 4.0 × 10^9 /L and a platelet count < 150 ×10^9 /L. Each patient included in the study underwent a series of investigations, including: blood count and reticulocyte count; peripheral blood smear examination; vitamin assays; bone marrow aspiration; immunophenotyping; osteomedullary biopsy (OMB) and serologies. Patients already diagnosed and under treatment, as well as patients under 18 years of age, were excluded from the study. Results: A total of 164 patients with pancytopenia were identified during our study period. The mean age of our patients was 48 years [extremes 18y-89y], with a preponderance of women (87women/77men). Mucocutaneous pallor was present in 100% of our patients, hepatosplenomegaly in 22.56% and hemorrhagic syndrome in 18.29%. Infectious syndrome and bone pain were observed in 12 patients (7.31%) and 05 patients (3.04%) respectively. Nineteen (19) patients had microcytic anemia, 85 had normocytic anemia and 60 patients had macrocytosis. Vitamin assays revealed vitamin B12 deficiency in 43 patients (26.91%), while 15 patients (9%) had folate deficiency. Combined B12 and folate def

ABSTRACT
The current article deals with the concept of Knowledge, Attitude& Practices (KAP) that emerged from the family planning programs after independence of the nation. Further, the concept of KAPGap emerged regarding the improvement of quality of the family planning programs. Development of the concept of KAP gap helped improved the quality of the family planning program & the program name changed to Family Welfare program. Further, it also provided a cafetoria approach of family planning methods where the people had to choice to chose from the available basket of methods of family planning/welfare. The current article traverses the history of the KAP approach, thereafter it sees how it sailed through finally reaching the current status of the KAP approach through the indicator of unmet need of family planning through the National Family Health Surveys of 4th& 5th rounds.

ABSTRACT
Streptomyces sp. play important role in controlling pathogenic bacteria by using different mechanisms so this study aims to diagnose the Streptomyces sp. and select strains having the ability to inhibit biofilm-forming bacteria and degradation proteins and starch. The capacity of bacteria to produce biofilms was examined by staining with 1% crystal violet. The ability to inhibit biofilm-forming bacteria, proteolytic and amylolytic, were determined by bacterial drop and well diffusion methods. The bacteria capable of creating biofilms were isolated from urinary tract infection and identified by biochemical reactions and sequencing the 16S rRNA gene. The Selected 6 Streptomyces strains which were isolated from soil are capable of inhibiting the growth of Escherichia coli and capable of degrading protein and starch. The strain STV1 was selected for 16S rRNA gene sequencing with standard isolates. Isolation of Escherichia coli capable of forming biofilm from urinary tract infection. Selection of Streptomyces sp strains capable of inhibiting biofilm-forming bacteria. The research is the first step to studying the application of Streptomyces sp in inhibiting biofilm-forming bacteria and in treating organic matter.