ABSTRACT
Persistent cytopenias, defined by a prolonged decrease in blood cells, are common clinical signs in various malignant hematological disorders, such as myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Diagnosis relies on a thorough evaluation, including biological tests, notably bone marrow analysis, and sometimes genetic and molecular tests. Treatment of these conditions includes azacitidine and venetoclax, whose combined effectiveness has shown promising results, although side effects such as neutropenia require careful management. This article presents a case of AML treated with this combination, with continuous evaluation of disease progression, genetic mutations, and treatment resistance.

ABSTRACT
Abstract: Haematopoietic stem cell transplantation, chemotherapy, and radiation therapy are frequently linked to the crippling condition known as oral mucositis (OM). It can seriously impair quality of life and possibly interfere with cancer treatment plans. It manifests as painful ulceration, erythema, and oedema. Microbiota dysbiosis, oxidative stress, and inflammatory pathways are all intricate components of the pathophysiology of OM. Its severity is influenced by several risk factors, such as chemotherapy, radiation dosage, genetic predisposition, and oral hygiene. There is still no ideal gold-standard treatment for it, despite its high prevalence. Pharmacological interventions like cytoprotective agents, anti- inflammatory medications, growth factors, biological response modifiers, and antimicrobial agents are all part of the multimodal approach used in current management strategies. Low-level laser therapy (LLLT), cryotherapy, and dental hygiene practices are examples of non-pharmacological methods that have demonstrated promise in reducing symptoms and enhancing patient outcomes. Recent developments in OM pathophysiology and treatment approaches are compiled in this review, which highlights the importance of tailored, evidence-based treatment plans. To improve patient care and reduce OM-related morbidity, more research is necessary to create innovative, affordable, and widely recognized treatments.

ABSTRACT
Introduction: Gerontology defined by the Royal Spanish Academy as the science that deals with old age and the phenomena that characterize it. Likewise, knowledge of the sciences of aging has relevant importance in clinical application, specifically at the first level of health care Objective: Identify and reflect on the applications of gerontology as a science in the clinical setting Methodology: A systematic review of scientific literature on gerontology carried out, using scientific search engines: Latindex, Scielo, PubMed and Semantic Scholar. In this sense, two categories focused on for the systematic analysis of the information: 1) Gerontological conceptual approaches, and 2) Professional competencies in the clinical field. Results: Nine articles published between 2016 and 2023 reviewed. In this sense, the identified findings are conceptual approaches and intervention methods in the clinical setting Conclusions: Gerontology is a science with little scientific literature and sufficient research regarding clinical intervention in professional settings. Consequently, recommended to design and execute actions from Higher Education Institutions and public policy to highlight the importance of gerontology in society.