ABSTRACT
Objective: Oral submucous fibrosis (OSF) is a chronic condition of the oral cavity which results in permanent disability. A number of studies have proven that the management of premalignant diseases should include antioxidants. Therefore, a study was carried out to evaluate the efficacy of spirulina in the management of 40 oral submucous fibrosis in uttar Pradesh. Materials and Method: An study was conducted on 40 oral submucous fibrosis cases, 40 patients given spirulina capsules systemetically 500 mg twice daily for period of 6 months .The results were analyzed with tukey test and ANNOVA test. Result: The result showed statistically significant improvement in burning sensation whereas it was clinically significant in mouth opening and tongue protrusion. Conclusion: Spirulina can bring about clinical improvements in OSF patients. The observed effects suggest that spirulina can be used in management of OSF patients. However, studies involving larger samples and longer period of treatment follow up are suggested in the future.

ABSTRACT
Class III skeletal malocclusion is one of the less frequent but aesthetically impactful misalignments. It can be caused by maxillary hypoplasia or retrognathia, mandibular hyperplasia, or a combination of both. Its frequency varies between 2-11% of the global population, depending on the ethnic group. Diagnosis and treatment planning traditionally is determined by two-dimensional anteroposterior position using cephalometric analysis on lateral radiographs, with few studies analyzing bone volume rather than position, being of great importance for diagnosis and treatment planning. This study aims to measure maxillary volume and its anteroposterior position using CBCT (Cone Beam Computarized Tomography) in skeletal Class I, II, and III patients, establish the bone volume and determine if there is a correlation between volume, length and anteroposterior position using the Trujillo analysis as a reference. Tomographs of patients from the Orthodontic program of the Universidad Autonoma de Baja California with Class I, II, and III malocclusions were collected. The maxilla was segmented using the DIAGNOCAT software, and teeth removed to measure the volume. The skeletal groups were divided for measurements to determine the patient's sex and search for volume, length and anteroposterior position, using for the last two variables the Trujillo’s analysis to compare them. ”T” students test was used for statistical analysis. There was a statistically significant difference in maxillary length and volume when comparing Class III patients to Class I and Class II, with Class III patients exhibiting lower values. No significant difference was found in the anteroposterior position of the maxilla when comparing the Class III group to the Class II skeletal group.