ABSTRACT
This prospective observational study was carried out to compare the symptomatic response and acceptable toxicity in concurrent chemo-radiotherapy and radiotherapy alone in the treatment of cervical cancer. A total of 60 patients (30 patients in arm A & 30 patients in arm B) who have biopsy proven cervical carcinoma with no history of previous treatment were selected from the Department of radiotherapy Rajshahi Medical College Hospital, Rajshahi & in the department of Radiation & Oncology, National Institute of Cancer Research & Hospital. All patients in both arms received external beam radiation with 50Gy in 25 daily fractions over five weeks. Followed by three insertions (one insertion per week) of Intracavitary brachytherapy each 700 cGy. Patients in arm-A received Inj. Cisplatin 40mg/m2 in IV infusion on the first day of each treatment per week in addition to radiotherapy. In this study it was observed that a significant symptomatic improvement was found in arm-A after treatment than arm-B and no severe unwanted reaction was noted in most of the patients. Systematic toxicity developed in both groups and comparatively more in arm-A (chemo radiation) but that was not statistically significant and well managed with conservative treatment. Regarding performance status patients treated with concurrent chemo radiation showed better performance status than the patient treated with radiotherapy alone. In this study it was observed that patients of carcinoma cervix treated with concurrent chemo radiotherapy was effective for symptomatic improvement and feasible with acceptable toxicity for advanced cancer of the uterine cervix than those with radiation alone.

ABSTRACT
Hypertension is an important risk factor for the development of numerous cardiovascular diseases. The prevention of hypertension is vital in the reduction of cardiovascular disease mortality and associated morbidities. Numerous studies have focused in the prevalence of hypertension and the prevalence of risk factors for cardiovascular diseases in Nigeria. However, this study investigated the knowledge of women in hypertension, perceived severity of hypertension and barriers towards engaging in hypertension prevention practices so as to establish key areas to focus public health promotion activities. This study was a cross sectional quantitative research carried out to investigate the pyschocognitive determinants of hypertension prevention practices among women residing in Akinyele Local Government Area of Oyo state in Southwest Nigeria. A total of 370 consenting women were recruited into the study using a multi-stage sampling technique and data was collected using the aid of an interviewer-administered questionnaire. Majority of study participants (74.9%) demonstrated fair knowledge of risk factors for hypertension while many participants (65.4%) had good knowledge of prevention practices for hypertension, with an overall mean knowledge score of 12.39±2.37 on a 24-point scale. Many participants (59.2%) had positive perception of severity of hypertension with a mean perception score of 23.80±2.814 on a 27-point scale. The most reported barrier towards engaging in hypertension prevention practices among participants was financial constraint in maintaining healthy eating habits. Furthermore, there is a significant association between participants’ level of education and their knowledge of hypertension. There is also a significant association between barriers towards hypertension prevention such as lack of awareness from media sources, financial constraint and knowledge of hypertension. The knowledge of hypertension among women in Akinyele Local Government Area ........

ABSTRACT
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder of hematopoietic stem cells. Misdiagnosed, patients suffer from true errancy of diagnosis mainly because of the large range of bio-clinical presentations. The following case of a 40-year-old male who went from an unexplored anemia to a falsely diagnosed systemic lupus then an Acute Kidney Injury (AKI) that required some dialysis sessions and later a kidney biopsy which the results threw us off track, highlights that exact problematic and showcases the accuracy and the simplicity of the test once the hypothesis strikes mind: The flow cytometry. Paroxysmal nocturnal hemoglobinuria must be evoked when there is a refractory anemia, a Coombs (-) anemia, thrombosis with hemolysis or cytopenia. The flow cytometry is considered the gold standard diagnostic tool.