ABSTRACT
The nutritious jujube fruit (Ziziphus jujube Mill.) is a member of the Rhamnaceous family and grows mainly in inland areas of Europe, southern and eastern Asia, Australia and especially northern China. Jujubes have a long history as fruit and medicinal. The main bioactive components are vitamin C, phenols, flavonoids, triterpenoids and polysaccharides. Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound of the hydroxycinnamic acid family found in the hydroethanolic fruit extract of Z.jujuba. This polyphenol has many health-enhancing properties, most of which are relevant for the treatment of metabolic syndrome, including antioxidant, anti-inflammatory, antilipidemic, antidiabetic, and antihypertensive effects. Methods: Molecular docking of COX2 with chlorogenic acid was carried out by AutoDock. Result: The molecular docking result revealed that chlorogenic acid showed encouraging docking score. The docking score found to be -5.15.

ABSTRACT
Manganese is a naturally occurring element and an essential nutrient. It is an essential trace metal that is involved in bone formation, brain development and in the metabolism of carbohydrates, cholesterol and amino acids. Excessive exposure of humans to manganese can result in a neurologic and psychological disorder called Manganism. This study assesses the effect of Manganese on the cerebellar cortex of adult wistar rats. Thirty-six (36) adult wistar rats were picked at random and divided into 4 groups with 9 animals each. Group A which was the control received distilled water, group B, group C and Group D received orally 0.3 mg/kg, 0.6 mg/kg and 0.8 mg/kg body weight of Manganese Chloride respectively for 29 days. Experimental Animals were sacrificed on the 30th day by cervical dislocation. The cerebellum were collected after sacrifice, weighted and fixed in 10% formol calcium and subsequently processed for histological observation using Hematoxylin and Eosin staining principle. Part of the cerebella cortex was homogenized for MDA, NO and SDH analysis. The result shows that the mean body weights decreased significantly in the manganese- treated groups when compared to the control. The mean brain weight of the Manganese Chloride treated groups B, C and D Insignificantly Increased compared with the control. Biochemical analysis of the MDA (Lipid Peroxide), NO (Nitric Oxide) and SDH (Succinate Dehydrogenase) Increased Significantly (P<0.05) in the Manganese treated group compare with the control. Histological analysis showed loss and degenerated neurons particularly the Purkinje cells in the cortical layers of the Manganese treated groups compare with normal Cerebella histoarchitecture in the control. This study concluded that Wistar rats treated with Manganese Chloride demonstrated neurodegenerative changes in the cerebella cortical layers, which may adversely affect some cerebella functions in the Wistar rats investigated.

ABSTRACT
The purpose of the current study was to use the solid dispersion approach to improve the solubility of the medication oxcarbazepine, which is only moderately water soluble. The antiepileptic medication oxcarbazepine is used to treat seizures. Due to its high permeability and low water solubility, it falls under BCS class II. To prevent issues of this nature, it was imperative to increase the solubility of oxcarbazepine in accordance with British Pharmacopoeia (BP) solubility criteria since pure oxcarbazepine falls under the category of being only very slightly soluble. Solid dispersion technique has been used to try and increase the solubility of pure oxcarbazepine. Oxcarbazepine is also extensively metabolized by the liver. Attempt has been made to formulate solid dispersions containing oxcarbazepine to improve its solubility and dissolution rate to avoid first pass metabolism; to avoid difficulty.

ABSTRACT
According to the General Health-System pharmacists have an obligation to take part in the infection control initiatives of Hospital. This duty results, in part, from pharmacist' comprehension of and control over the use of antibiotics within the healthcare system. Additionally, the National Health Mission thinks that participation on multidisciplinary work groups and committees within the health system is the best way for pharmacist to effectively participate in infection control programmes and support the appropriate use of antibiotics throughout the health system. These initiatives should reduce the likelihood of antimicrobials being misused, lowering the danger of infection for other patients and staff members while also improving the treatment outcomes for patients with infectious disorders.

ABSTRACT
Probiotics are employed in therapeutic settings and for consumers who are typically healthy. However, probiotic intake can have both hypothetical and real negative effects. Probiotics should be used safely and effectively, which calls for clear, doable suggestions on how to proceed in light of the introduction of new probiotic strains and products as well as the expansion of their usage among vulnerable groups. The International Scientific Association for Probiotics and Prebiotics called a meeting to discuss and develop evidence-based recommendations on potential acute and long-term risks, risks to vulnerable populations, the necessity of adverse event reporting related to probiotic use, and the importance of probiotic product quality to match the needs of vulnerable populations. In the present review we focused the ICMR- DBT guidelines for the evaluation of the probiotics and current regulatory status with reference to the probiotics.

ABSTRACT
Background: University studying is demanding on the mental as well as the physical side of the students. However, studying medicine is even more challenging – the study is six years long, and it is tough to remember more information. The study changed the social life of students, and the students didn't have enough time to relax. The examinations of students are full of stress. Stress harms health, especially in the gastrointestinal tract (autonomic nervous system). Aims: The first study evaluated eating habits during and outside an examination period and the effect on the health of medical students in Slovakia. Methods: We made the questionnaire and distributed it online to medical students at the Faculty of Medicine in Bratislava, Slovakia. A total of 587 students from the 1st to 6th year completed self-report measures of BMI, academic stress, eating habits and the occurrence or development of digestive problems during the study. Results: Our results showed that most respondents were of average range weight and ate a well-balanced diet (90%); more than half of the participants had breakfast regularly, and almost half of the students ate junk food a few times per week. Our participants consumed less food but more junk food and energy drinks during the exam period, which can cause obesity and digestive problems. Conclusion: Our findings confirm that subjective academic feelings of stress play an important role in eating habit changes and in the origin of digestive disorders in our medical students.