ABSTRACT
Objective: To determine the epidemiological and histological aspects of primary malignant bone tumors in Cameroon. Materials and Methods: A descriptive retrospective study of patients with confirmed malignant primary bone tumors biopsy presented between January 2004 and December 2017 in all anatomo-pathological laboratories in Yaounde and Douala, which are the two biggest towns in Cameroon. Patients with multiple myeloma and lymphoma were excluded. Results: A total of 234 bone tumors were found. 56.41% (132 cases) of these tumors were benign tumor, 38.41% (90 cases) were malignant tumors and only 12 (5.11%) were metastases. The average age of the patients with malignant tumors was 27.95 ± 17. 93 years, with extremes of 5 and 80 years. Female was the most represented with 51.11% (46 cases), with a male-to-female sex ratio of 0.96. The site most affected by malignant bone tumors was the femur 33.3% (30 cases), the tibia 22.2% (20 cases). Osteosarcoma was the most common histological diagnosis (52 cases, 57.8%); followed by Ewing’s sarcoma (15 cases, 16.6%) and chondrosarcoma (11 cases, 12.2%), fibrosarcoma (5 cases, 5.6%), angiosarcoma (4 cases, 4.4%) and liposarcoma (3 cases, 3.3%). Conclusion: Primary malignant bone tumors occurred between first and second decade of life with male preponderance. Osteosarcoma was the most common malignant bone tumors, respectively. The femur and tibia was the preferred affected site. Keywords Malignant tumor, Bone, Cameroon

ABSTRACT
Abstract: Recent progress regarding the potential benefit of dietary antioxidants in the treatment of chronic diseases with a special focus on immune system and neurodegenerative disorders will be discussed here. It is well established that reactive oxygen species (ROS) play an important role in the etiology of numerous diseases, such as atherosclerosis, diabetes and cancer. Among the physiological defense system of the cell, the relevance of antioxidant molecules, such as glutathione and vitamins is quite well established. Recently, the interest of researchers has, for example, been conveyed on antioxidant enzyme systems, such as the heme oxygenase/biliverdin reductase system, which appears modulated by dietary antioxidant molecules, including polyphenols and beta-carotene. These systems possibly counteract oxidative damage very efficiently and finally modulate the activity of oxidative phenomena occurring, for instance, during pathophysiological processes. Although evidence shows that antioxidant treatment results in cytoprotection, the potential clinical benefit deriving from both nutritional and supplemental antioxidants is still under wide debate. In this line, the inappropriate assumption of some lipophylic vitamins has been associated with increased incidence of cancer rather than with beneficial effects. Background: This study aims to investigate the effect of antioxidants supplement on clinical outcomes and antioxidant parameters in rheumatoid arthritis (RA). Methods: The pre-post study was conducted on 40 female patients with RA in 12 weeks that taken daily one Selenplus capsule contained 50 μg selenium, 8 mg zinc, 400 μg vitamin A, 125 mg vitamin C, and 40 mg vitamin E. About 5 mL venous blood sample was taken from all participants and disease activity score (DAS) was determined by DAS-28 formula and high-sensitive C-reactive protein (hs-CRP). Glutathione peroxidase (GPX) and superoxide dismutase (SOD) were measured by spectrophotometric kit and catalase

ABSTRACT
Abstract: Boerhaave's syndrome is a rare but lethal disease involving the gastrointestinal tract. It is a spontaneous esophageal perforation with complete transmural tear caused by a sudden increase of intraluminal pressure in the esophagus. The disease is associated with high mortality of more than 40% with early surgical intervention. Delayed surgical intervention more than 7 days after the initial presentation is associated with nearly 100% mortality. The classical Mackler's triad of symptoms is rare. The reported rate of misdiagnosis is high. Delayed presentation, misdiagnosis, and intervention is associated with poor healing, increased complications, prolonged hospital stay, and increased mortality. We report two cases of Boerhaave's syndrome. One case presented early within 24hours with classical symptoms, while another presented late after 7 days with atypical symptoms and a delayed diagnosis elsewhere. Both the cases where managed by recommended standard practices. Despite minimal complications, the patient with early presentation had a comparatively good healing, early recovery, and short hospital stay. The patient with delayed presentation had already developed multiple complications at presentation to our setup. Though this patient required a prolonged hospital stay, an intensive, imaginative, and aggressive multidisciplinary care resulted in a good recovery. A high index of suspicion and early intervention helped in the recovery and prevention of complications in patients presenting early. Good multidisciplinary care resulted in a good recovery in the patient with delayed presentation. With a good and imaginative multidisciplinary care, even a condition with a mortality rate as high as 100% can be managed successfully. Keywords Boerhaave Syndrome, Mediastinitis, Esophageal Perforation.