ABSTRACT
The purpose of this study is to investigate the effects of extract of Eugenia uniflora on some haematological parameters of male Wistar rats. A total of 24 male Wistar rats were used in the study. They were divided into four groups of six (6) rats each. Group 1 functioned as the control group and received distilled water while Groups 2, 3 and 4 received 200mg/kg, 400mg/kg and 800mg/kg extract of Eugenia uniflora respectively. The administration was done orally once daily for 30 days. At the end, the rats were sacrificed under light chloroform anaesthesia and their blood collected for analysis of haematological parameters. Data was analysed using SPSS version 23 (SPSS incorporated, Chicago, Illinois, USA). Results are expressed as mean±standard error of mean (SEM). Significant differences were determined by one-way analysis of variance (ANOVA). The differences in values were considered to be statistically significant at p<0.05. The packed cell volume (PCV) decreased significantly in some test groups when compared to control. The RBC count and Hb concentration also decreased significantly. There was a significant increase in white blood cell count amd neutrophils but reductions in lymphocytes and mean corpuscular haemoglobin concentration. Result of the study has shown that the hydromethanolic extract of Eugenia uniflora may possess anti-erythropoietic actions because of the significant reductions in RBC count and Hb concentration as well as leucopoetic and possibly immunomodulatory actions which boosted white blood cell (WBC) production.

ABSTRACT
Haemophilia is an inherited bleeding disorder. The blood does not clot as it should, which can result in spontaneous bleeding and bruising after surgery or other injuries. Hemophilia A is an X-linked, recessive disorder caused by deficiency of functional plasma clotting factor VIII, which may be inherited or arise from spontaneous mutation. Hemophilia B, is an X-linked inherited bleeding disorder, usually manifested in males and transmitted by females who carry the causative mutation on the X chromosome is a deficiency of factor 1X. We are presenting a case of 34years old man with the complain of bilateral neck swelling for 5days,difficult in swallowing and breathing for 3days.Emergency tracheostomy was done and admitted to the ICU thereafter CT-scan was done and showed retropharyngeal swelling. The excision of the mass was done whereby hematoma was evacuated. Patient was admitted to the ICU for about two weeks then transfer to the wards. The laboratory test revealed deficiency of factor V111.