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To study proportion of population of hypertensive emergencies presenting with neurological complications in intensive care unit Materials And Methods: This present observational study has been conducted in Department of General Medicine, D.Y Patil Hospital, Nerul, Navi Mumbai.A written signed informed consent has been taken prior to enrolling the subjects in the study. Study Design: Prospective observational study Study Site: Emergency, ICU, Department of General Medicine, D.Y Patil Hospital, Nerul, NaviMumbai Duration Of Study: September 2018 – December 2019 Sample Size: All consecutive number of patients presenting with hypertensive emergencies admitted in ICU, D.Y. Patil Hospital, Nerul, Navi Mumbai fitting the inclusion criteria during the entire duration of study).

ABSTRACT
Recording a flabby tissue in completely edentulous patients is a common occurrence in dental practice. The principle of recording such tissue is based on the mucostatic theory of impression making which has given rise to the commonly followed window technique of recording flabby tissue. The technique requires to paint the impression plaster over the flabby ridge in a dual impression. We present a different technique that utilizes the principle of hydraulics through the use of a plastic disposable syringe. The technique is simple, inexpensive and falls within the norms of scientific principles.

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Perforation of the hard palate is multi causal in nature and depending on its cause, the extent and location varies. A male patient aged 29 years was referred for prosthetic rehabilitation of a perforation of the hard palate. The patient had difficulty in swallowing, phonetics, nasal regurgitation of food since the perforation was large and extended to the soft palate. Treatment plan consented by the patient was a fabrication of hollow obturator followed by speech therapy. The hollow part of the obturator was fabricated using a soluble water based clay which dissolves upon contact with water. The obturator was retained by a combination of interproximal acrylic extension and various clasps. The obturator was retentive and met the satisfaction level of the patient.

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A cast partial denture prosthesis is generally not desired by a patient, but in certain cases it remains the only option since there are many patients where a fixed form of partial dentures are not indicated. It is also least practiced by general practitioners while it is of academic interest at higher education level. We present a case of a cast partial denture that not only had to oppose another cast partial denture but both partial dentures had modification edentulous spaces in it. The level of education and motivation that the patient requires in such cases is briefly discussed.

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This study aims to determine the number of sufferers, disease patterns based on sex, age, radiological features, type of surgery performed, place of treatment, results of postoperative Anatomy Pathology and the condition of post-treatment patients in cases of abdominal tumors in children. This research method is descriptive retrospective. Retrospectives were obtained in Dr. Hospital's medical records Wahidin Sudirohusodo from 2014 to 2017. The results of this study showed that cases of malignant abdominal tumors in children were found 83 cases, the distribution of 44 cases (69.23%) and 39 cases (30.77%) for women, the youngest age was 6 months and the oldest is 16 years, most at the age of 3-6 years. Abdomen ultrasound examination and CT scan Abdomen tumor location of the most nephroblastoma 23 cases (44.23%). Surgery was performed in 38 cases (65.71%), the results of Anatomical Pathology after nephroblastoma surgery were 25 cases (48.07%). The surgical department treated 35 cases (67.30%) and pediatric 17 cases (22.70%). This type of surgery performed 11 cases (47.82%) nephrectomy, 4 cases (17.39%) biopsy laparotomy and 8 cases (34.78%) laparotomy removal of the tumor. The condition of the patient when healed 10 cases (43.47%), forced to go home 7 cases (30.43%) and died 6 cases (26.2%) The average patient with a malignant abdominal tumor in children came with an advanced stage. Not a good recording and monitoring system causes the final results can not be well known.

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Spindle cell squamous cell carcinoma is a rare poorly differentiated variant of Squamous cell carcinoma composed predominantly of spindled tumour cells with partial or complete loss of morphological squamous cell differentiation which has to be differentiated from other spindle cell tumours like atypical fibromyxoxanthoma, superficial undifferentiated pleomorphic sarcoma and spindle cell melanomas. Here we present a case report of a unique presentation of spindle cell squamous cell carcinoma in a middle aged Indian man.

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Objective: To investigate Serum Uric Acid levels, HbA1c levels in patient’s withType II Diabetes mellitus and compare with normal subjects. Methodology: The present study is a case control study conducted at Navodaya Medical College Hospital and Research Centre, over a period of 1 year. 100 participants were divided into 2 different groups, Cases and Controls. Cases included 50 patients with Type II Diabetes Mellitus and controls included 50 matched participants who didn’t have Type II Diabetes mellitus, both the groups fulfilling the inclusion criteria and exclusion criteria. Serum uric acid, blood sugar levels, HbA1c levels were measured in both controls and patients. Results: The serum uric acid levels were low in cases, compared to controls (mean in cases 3.4890 mg/dl compared to 4.8600 mg/dl in controls). The HbA1c levels negatively correlated with serum uric acid, i.e.; as HbA1c increased, serum uric acid levels decreased (p value < 0.001; highly negatively correlated). Conclusion: Serum Uric Acid levels were low in patients with Type 2 Diabetes Mellitus, particularly in those who had poor glycemic control. This may be due to increased excretion of serum uric acid during hyperglycemia and glycosuria.

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Introduction Coagulation factor IX (FIX) is considered a prothrombotic risk factor. Its increased plasma levels and activity are associated with a significantly increased risk of arterial and/or venous thrombosis. The indicator has been poorly studied in atrial fibrillation (AF).Aim To examine FIX as indicator of coagulation activity in the early hours (up to 24 hours) of the clinical manifestation of paroxysmal atrial fibrillation (PAF).Material and methods 51 non-anticoagulated patients (26 men, 25 women, mean age 59.84±1.60) with PAF and 52 volunteer controls (26 men, 26 women, mean age 59.50±1.46 years) matched in gender, comorbidities, and treatment were selected for the study. FIX plasma coagulation activity was examined using a photometric test.Results All patients were hospitalized between the 2nd and 24th hours after the arrhythmia onset (mean 8.14±0.74 hours). PAF group showed higher FIX activity relative to the control group (170.43%±6.62% vs 117.72%±5.95%, p<0.001), independent of age and BMI (p>0.05), and slightly dependent on PAF duration (r=0.38, p<0.05). Male gender (186.82%±8.98% vs 154.70%±8.38%, p<0.05) and high embolic risk (CHA2DS2-VASc score≥2) (156.03%±8.62 vs 184.31%±8.99%, p<0.05) were associated with higher FIX activity. ConclusionFIX activity is elevated even in the first twenty-four hours of the clinical manifestation of PAF. This gives reason to believe that the intrinsic coagulation cascade pathway is activated, which determines the early expression of PAF as a procoagulant state. At the same time, it is a prerequisite for FIX to become a new target for AF anticoagulant therapy with good antithrombotic efficacy and reduced bleeding risk.

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The Bundelkhand region of central India is different geographically, socially and economically. It is a semi-arid plateau area. This region is marked by extremes of temperature. The climatic and geographical conditions in this region favours the development of skin diseases. Studies have shown that several variants of psoriasis are developed in this region. Aims: The aim of this present study was to investigate the immunohistochemical expression of VEGF and Survivin in psoriatic skin and to detect their role in the pathogenesis of Psoriasis so that therapy could be targeted against suvivan and angiogenesis in the treatment of psoriasis patients. Settings: A retrospective case control study in a tertiary referral centre. Material & methods: A total of 54 cases were taken who visited the Dermatology OPD from January 2016 to october2017. These cases were diagnosed as Psoriasis after histopathological examination. Each case was subjected to general examination, H&E staining (Culling 1975) and immunohistochemistry with VEGF and Survivin. Results: Maximum 37% cases shows cytoplasmic VEGF staining in epidermis, dermis & blood vessels. 13% cases shows VEGF staining in epidermis and blood vessels. 30 cases showed nuclear and cytoplasmic SURVIVIN staining in epidermis. 26 cases shows Survivin staining in epidermis + sweat glands .The value of |Z| obtained is 5.04216 and p<0.0001 implies that there is high significant difference between Psoriasis studied with age and duration of Psoriasis. Conclusion: Over expression of survivin in psoriasis denotes its important role in the apoptosis suppression as a possible mechanism in the pathogenesis of Psoriasis so that survivin targeted therapies can be benifited in the treatment of psoriasis.

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Background: Nanotechnology is a fast growing field that provides for the development of materials that have new dimensions, novel properties, and a broader array of applications. It is now known that the toxic behavior of NPs differ from their bulk counterparts. Even NPs that have the same chemical composition differ in their toxicological properties; the differences in toxicity depend upon size, shape, and surface covering. Hence, before NPs are commercially used it is most important that they be subjected to appropriate toxicity evaluation. Objectives: The aim of the present study was to evaluate the nephrotoxicity induced by CuO and/or Zn-O nano- particles in male rats. Materials and Methods: Twenty adult male rats were grouped randomly into four groups (n=5 each group). Group I (control): Rats were injected with saline intraperitoneally and at a dose of 1.0 ml/kg b.w. for 28 days. Group II (ZnONPs): Rats were administrated orally with ZnONPs (10 mg/kg/day) for 28 days. Group III (CuONPs): Rats were injected with CuONPs (0.5 mg/kg/day, in saline; intraperitoneally) for 28 days. Group IV (ZnONPs + CuONPs): Rats were given orally ZnONPs (10 mg/kg/day) follwed by injected with CuONPs (0.5 mg/kg/day, in saline; intraperitoneally), for 28 days. At the end of the experimental period, rats were anesthetized using light ether. Blood and kidney tissue samples were taken and prepared for biochemical and histological measurements. Results: Serum urea concentration was elevated due treatment of rats with CuONPs, ZnONPs and their mixture compared to control group. Also, CuONPs increased serum uric acid, while ZnONPs reduced serum uric acid and increased creatinine concentration compared to the control group. Treatements of rats with nanoparticls mixture elevated uric acid and creatinine concentration. histopathological abnormalities were observed in kidney of rats treated with CuO-NPs, ZnO-NPs, and CuO-NPs + ZnO-NPs. CuO-NPs, ZnO-NPs, and CuO-NPs + ZnO-NPs –induced histopath

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Introduction: MRSA is one the most common cause of nosocomial infections. Decolonization of MRSA from the anterior nares by mupirocin ointment is most commonly performed modality to prevent the transmission of infection among patients and health care personnel. Unprecedented use has led to development of resistance to mupirocin. The present study is conducted to determine the prevalence of mupirocin resistant S. aureus to understand the risk of transmission of nosocomial infections due to S. aureus in our health care setting Materials and methods: All clinical isolates of S. aureus obtained from various specimens sent for routine culture and sensitivity in the laboratory was included in the study. Methicillin resistance was determined by using cefoxitin disc 30 μg as per Clinical and Laboratory Standards Institute (CLSI) guidelines. Mupirocin resistance among S. aureus was determined by disk diffusion method using mupirocin discs of 5 μg and 200 μg. Results: Out of 310 S. aureus isolates, 141 isolates were MRSA. Mupirocin resistance among the MRSA isolates was found in 9 (6.4%) isolates. Among the mupirocin resistant strains, none of the isolates showed low-level of mupirocin resistance. Conclusion: Routine nasal decolonisation of health care personnel and surveillance of mupirocin resistance among the isolates obtained from the patients and the health care personnel should be done to prevent the transmission of infections.