ABSTRACT
Introduction: Myelomeningocele repair is a relatively uncommon procedure. Much of this has been attributed to improve nutrition and early detection. Our aim is to detect early (30 days) outcome of pediatrict patients undergoing postnatal myelomeningocele repair. Material and Methods: The prospective observational study was carried out on 68 patients presented with myelomeningocele who underwent surgery with age ranged from one (1) month to two (2) years got admitted in the department of neurosurgery, Bangabandhu Sheikh Mujib Medical University from January 2020 to May 2023. Results: Maximum age was found 1 month to 3 months, female baby were predominant which was 40(58.8%), majority 48(70.6%) were medium size, common location were Dorsal (14.7%), Lumbar (45.6%) and Dorsolumbar (33.8%). CSF leak found (8.8%), decreased power of limbs found (38.2%), wound infection was found (5.9%), hydrocephalus found (39.7%), New hydrocephalus (2.9%) and New neurological deficit (1.5%). The duration of hospital stay 4.1±0.8 days. Conclusion: Most complications occur within 30 days of myelomeningocele repair. Wound infection was found in 5.9%. Mostly occurs between 1 to 3 months of age. Early repair of myelomeningocele reduces neurological impairment significantly.

ABSTRACT
The use of anti-TNFs in Crohn's disease (CD) is often associated with the appearance of antinuclear antibodies, and more rarely with anti-native DNA antibodies. Anti-TNF-induced lupus remains exceptional. We report the case of a 52-year-old woman, followed for colonic Crohn's disease, treated with Infliximab. After 12 months of treatment with anti-TNF alpha (Infliximab), the patient developed clinical and biological lupus with positive antinuclear antibodies (ANA) and anti-native DNA antibodies (IgG). Infliximab treatment was discontinued. Six months after stopping the treatment, the patient had no recurrence of clinical signs, and immunological examinations showed a marked decrease in total ANA and anti-native DNA antibodies (IgG).

ABSTRACT
Dermatofibrosarcoma (DFS) is a fibrous tumor of the skin, slow growing, with a very high risk of local recurrence, but with a low metastatic potential associated with a specific chromosomal translocation. It is found more frequently in adults and the elderly. The curative treatment is surgical by a wide excision laterally and in depth. This excision results in large losses of substances, the coverage of which is a real challenge for the surgeon and requires different means ranging from skin grafts to free musculo-cutaneous flaps. We report the case of a 49-year-old patient with a voluminous purplish polylobed anterior and upper thoracic mass. The radiological assessment revealed a superficial parietal dermal mass. He had a biopsy confirming the diagnosis of Dermatofibrosarcoma of Darried and Ferrand. The excision surgery allowed a wide and complete resection with directed recovery with excellent postoperative results without recurrence at 06 months. The aim of this article is to present the therapeutic procedure for this pathology taking into account the site of the tumor, the size, the time of occurrence, the number of recurrences, the clinical signs, the operating protocol, the results of the pathological examination and post-operative complications with a review of the literature.

ABSTRACT
Isolated iliac artery aneurysms are extremely rare, accounting for less than 2% of all aneurysmal diseases. These aneurysms are usually seen in older men. Very mildly symptomatic but carries a significant risk of rupture when the aneurysms have reached a large size. Their operative mortality is significantly higher when undertaken as an urgent or elective procedure, highlighting the importance of early diagnosis and appropriate management. The development of radiological exploration methods has facilitated the discovery and diagnosis of these aneurysms. The emergence of endovascular techniques constitutes an alternative to traditional surgical treatment. We report our surgical management of an aneurysm of the primary iliac artery isolated in a 71-year-old man, who benefited in our department from a resection of the aneurysm with restoration of continuity by a prosthetic bypass. The objective of this article is to present and describe the diagnostic assessment; imaging data, treatment methods as well as a review of the literature concerning the history of iliac artery aneurysms.

ABSTRACT
Introduction: The sequelae of burns induce variable functional, aesthetic and psychological repercussions. They can be minor or major. The sequelae of burns are basically attributable to two causes: the male therapy conducted and the severity of the burn itself. Objective: To describe the clinical and epidemiological characteristics of burn sequelae in the "young" Dermatology Hospital of Bamako in Mali. Methodology: A descriptive and transversal study carried up on patients with burns sequelae and operated in Dermatological hospital of Bamako at the plastic and oncological service from January 2017 to December 2020. The study population consisted of all the patients (138 cases) with burns sequelae. Result: The sex ratio was 1.06. The mean age was 13.73 years (range: 7 months to 74 years). The most affected age group was paediatric with 65.90% of cases and the dominant age group was 0 to 5 years old with 41.3%. Hot liquid was the most frequently found causative agent at 52.9%, followed by fire and hot metal at 31.2% and 8%, respectively. Flanges were the most dominant (56.80%), followed by cupboards (33.73%) and ulcers on old burns (4.73%). Conclusion: A well-conducted therapy would not only reduce the severity of burn sequelae but also avoid them, which would allow empowering patients after burns and reducing the high costs associated with the management of these sequelae.

ABSTRACT
Giant lipomas are voluminous benign mesenchymal tumors formed by fatty lobules from mature adipose tissue and whose exact etiological is not yet elucidated. We report the case of a 64-year-old patient with a giant lipoma at the hip with physical and psychological impact. Treatment was surgical and consisted of a wide excision of the mass. The surgical piece measured 378X303 mm and weighed 2600 grams. The surgical follow-ups were simple. The late management of lipomas can lead them to reach an inordinate size causing disabilities and increasing the possibility of neoplastic transformation. After excision, a pathological anatomopatological study is required to rule out a liposarcoma.

ABSTRACT
Photodynamic treatment (PDT) has emerged as a promising therapeutic approach for immune system diseases due to its ability to selectively target abnormal cells while modulating the immune response. This review explores the mechanisms by which PDT activates the immune system to target diseased cells, including the induction of immunogenic cell death, activation of dendritic cells, release of tumor-associated antigens, modulation of immune checkpoints, and induction of cytokines and chemokines. Additionally, PDT can generate reactive oxygen species, induce apoptosis, and exhibit anti-inflammatory and vascular effects, all of which contribute to its therapeutic potential in immune system diseases [1]. Harnessing PDT for immune system diseases offers a unique opportunity to leverage the immune system's inherent ability to recognize and eliminate abnormal cells, providing a targeted and potentially less toxic treatment option. Further research and clinical studies are warranted to fully elucidate the potential of PDT in the management of immune system diseases and to optimize its clinical application.